Purkinje cell

In cerebellar Purkinje cells, a TTX-sensitive inward current is elicited, when the membrane was partially repolarized after strong depolarization. This resurgent current contributes to high-frequency repetitive firing of Purkinje neurons. The resurgent current results from open channel block by the cytoplasmic tail of the (34 subunit. The med Nav 1.6 mutant mice show defective synaptic transmission in the neuromuscular junction and degeneration of cerebellar Purkinje cells. 

Kreitzer AC, Regehr WG. Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron 2001 29 717-727. 

Spinocerebellar Cerebellar cortex (Purkinje cells), 6-39 40-81 Ataxin-1 NI (n, c)... 

Rat (Sprague-Dawley) gd5-ppd21 7hr/d 20 (severe alterations in architecture and growth characteristics of Purkinje cell dendritic fields) Hannah and Roth 1991... 

Hannah and Roth (1991) exposed timed pregnant dams (and their pups) from day 5 postcoital, until day 21 postnatal, to either 20 or 50 ppm of hydrogen sulfide for 7 hours a day and found severe alterations in the architecture and growth patterns of the Purkinje cell dendritic fields at both doses leading these authors to conclude that exposure to low concentrations of hydrogen sulfide place developing neurons.. .at risk of severe deficits. ... 

Hannah RS, Roth SH. 1991. Chronic exposure to low concentrations of hydrogen sulfide produces abnormal growth in developing cerebellar Purkinje cells. Neurosci Lett 122 225-228. 

Nasmyth Aren t Purkinje cells the largest cells ... 

Subsurface cisternae are a system of smooth, membrane-bound, flattened cisternae that can be found in many neurons. These structures, referred to as hypolemmal cisternae by Palay and Chan-Palay [1], abut the plasmalemma of the neuron and constitute a secondary membranous boundary within the cell. The distance between these cisternae and the plasmalemma is usually 10-12 nm and, in some neurons, such as the Purkinje cells, a mitochondrion may be found in close association with the innermost leaflet. Similar cisternae have been described beneath synaptic complexes, but their functional significance is not... 

Neurons and glia exhibit a remarkable diversity of shapes. These different morphologies are so characteristic and distinctive that they have been used since the time of Cajal to define functional neural functions. For example, Purkinje cells in the cerebellum have such distinctive morphologies... 

Kano, M., Hashimoto, K., Kurihara, H. et al. Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluRl. Neuron 18 71-79,1997. 

Buffo, A., Zagrebelsky, M., Huber, A. B. et al. Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured Purkinje cell axons. /. Neurosci. 20 2275-2286, 2000. 

Bergersen, L., Waerhaug, O., Helm, J. et al. A novel postsyn-aptic density protein the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Exp. Brain Res. 136 523-34,2001. 

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