Purkinje cells NMDA receptor subunits

Taniguchi K, Shinjo K, Mizutani M, et al (1997) Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br J Pharmacol 122 809-812 Tempia F, Alojado ME, Strata P, KnOpfel T (2001) Characterization of the mGlnR(l)-mediated electrical and calcium signaling in Purkinje cells of mouse cerebellar slices. J Neurophysiol 86 1389-1397... 

Misra C, Brickley SG, Wyllie DJ, Cull-Candy SG. Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells. J Physiol 2000 525(Pt 2) 299-305. 

Adult Purkinje cells strongly express the NRl gene (Watanabe et al., 1994 Cull-Candy et al., 1998). All the NRl RNA splice variants are found, although NRl-3 (Cl only, see Fig. 6) RNA is at low levels (Laurie et al., 1995). However, according to most reports, adult Purkinje cells do not contain NR2-type subunit mRNA (Watanabe et al., 1994), and indeed have no detectable NMDA receptors (Cull-Candy et al., 1998) nevertheless, two groups have described NR2A mRNA in Purkinje cells (Akazawa et al., 1994 Luque and Richards, 1995). This has still not been resolved. The mismatch in expression between NRl and the NR2 series has been much commented on (Cull-Candy et al., 1998), and it is indeed unusual to find a neuron type with no NMDA response. An outside possibility is that the NRl subunit... 

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