Purkinje cells aldolase

Besides the variable functional outcome after ischemia in animal models, it is well established that specific neuronal populations within an individual vary substantially in ischemic tolerance. Neurons in the CA1 region of the hippocampus and other distinct cellular populations of the caudate, thalamus, neocortex and cerebellum are selectively vulnerable to relatively brief periods of ischemia (Kirino and Sano 1984 Siesjo 1988). The reasons for this phenomenon are not fully elucidated, but for example in cerebellar Purkinje cells it could be shown that a reduced level of aldolase may trigger energy failure after brief periods of anoxia (Welsh et al. 2002). Changes in microcirculation, as seen in focal stroke,... 

Welsh FA, Yuen G, Placantonakis DG, Vu TQ, Haiss F, O Hearn E,Molliver ME, Aicher SA (2002) Why do Purkinje cells die so easily after global brain ischemia Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus. Adv Neurol 89 331-359... 

However, Purkinje cells of the human cerebellum stand out from other nerve cells by their high content of aldolase-C (Royds et ah, 1987). 

Caffe AR, Von Schantz M, Szel A, Voogd J, Van Veen T (1994) Distribution of Purkinje cell-specific zebrin-ll/aldolase C immunoreactivity in the mouse, rat, rabbit, and human retina. J. Comp. Neurol, 348, 291-297. 

Royds JA, Ironside JW, Warnaar SO, Taylor CB, Timperley WR (1987) Monoclonal antibody to aldolase C A selective marker for Purkinje cells in the human cerebellum. Neuropath. Appl Neurobiol, 13, 11-21. 

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