Purkinje neurons

In cerebellar Purkinje cells, a TTX-sensitive inward current is elicited, when the membrane was partially repolarized after strong depolarization. This resurgent current contributes to high-frequency repetitive firing of Purkinje neurons. The resurgent current results from open channel block by the cytoplasmic tail of the (34 subunit. The med Nav 1.6 mutant mice show defective synaptic transmission in the neuromuscular junction and degeneration of cerebellar Purkinje cells. 

Weimann, J. M., Johansson, C. B., Trejo, A and Blau, H. M. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat. Cell Biol. 5 959-966, 2003. 

Harmaline has also been found to have neurotoxic effects on Purkinje neurons (O Hearn and Molliver 1997). This likely results from excitotoxic consequences induced by prolonged stimulation of inferior olivary neurons. Whether this occurs in levels reached during human consumption has not been specifically addressed. Prolonged neurological symptoms have not been reported in those who consume the drug. 

Ukena K, Usui M, Kohchi C, Tsutsui K. 1998. Cytochrome P450 side-chain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in rats. Endocrinology 139 137-147. 

Tin, A.M., Freund, R.K., Hoffer, B.J., and Palmer, M.R. (1994) Ethanol-induced depressions of cerebellar purkinje neurons are potentiated by beta-adrenergic mechanisms in rat brain. / Pharmacol Exp Tfer 271 1175-1180. 

PMCA2 is expressed strongly in Purkinje neurons of the cerebellum (Stahl et al.,... 

P Cerebellar Purkinje neurons Long, high threshold [Pg.274]

Synergism between DSE and eSTD has been observed in elegant studies by Brenowitz and Regehr (2005). Parallel fiber synapses onto cerebellar Purkinje neurons exhibited both types of synaptic depression, and stimuli that are subthreshold for induction of either type of depression alone can be co-activated to yield depression. This synergism is dependent on both postsynaptic calcium levels and mGluR activation, but the mGluRs do not appear to participate in the calcium rises crucial for induction of depression. 

Presynaptic NMDA receptors have also been reported to control GABA release. At intemeuron synapses onto Purkinje neurons, activation of NMDA receptors raised spontaneous GABA release, and this effect lasted for more than 10 minutes voltage-gated Ca2+ channels were not involved, but a blockade of ryanodine receptors attenuated the enhancement of GABA release and restricted the effect by time... 

We have previously isolated a 48-amino-acid peptide, named (u-agatoxin-TK (co-Aga-TK), from the venom of the funnel web spider, Agelenopsis aperta. It was found to be a potent blocker of the P-type calcium channels in rat cerebellar Purkinje neurons, but... 

Strahlendorf, J.C., Box, C., Attridge, J., Diertien, J., Finckbone. V., Henne, W.M., Medina, M.. Miles, R., Oomman, S., Schneider, M., Singh, H., Veliyaparambil, M., and Strahlendorf. H., 2003. AMPA-induced dark cell of cerebellar Purkinje neurons involves activation of caspases and apparent mitochondrial dysfunction. Brain Res., 994, pp. 146-159. 

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