Purkinje cells axon collaterals

Fig. 2. Diagrams of the cerebellar circuit. Inhibitory neurons are indicated in black. A. Main circuit. B. Cortical interneurons and recurrent pathways. Abbreviations B = basket cell cf = climbing fiber G = Golgi cell GR = granule cell 10 = inferior olive mf = mossy fiber nc = nucleocortical axons no = nucleo-olivary axons pcc = recurrent Purkinje cell axon collaterals P cell = Purkinje cell PCN = precerebellar nuclei pf = parallel fiber pi = pinceau of basket cell axons S = stellate cell UBC = unipolar brush cell I = extracerebellar mossy fiber 2 = nucleo-cortical mossy fiber 3 = mossy fiber collateral of uni-polar brush cell.

Bishop GA, Blake TL, O Donoghue DL (1987) The distribution pattern of Purkinje cell axon collaterals variations on a theme. In King JS (Ed.), New Concepts in Cerebellar Neurobiology. Alan R. Liss, New York, 29-56. 

O Donoghue DL, Bishop GA (1990) A quantitative analysis of the distribution of Purkinje cell axonal collaterals in different zones of the cat s cerebellum an intracellular HRP study. Exp. Brain Res., 80,63-71. 

Fig. 8. Purkinje cell of rat cerebellum. Intracellular injection with lucifer yellow and staining with anti-lucifer yellow antibody. PAP method, cresyl violet counterstained. Note plexus of beaded axon collaterals in A and B and spiny branchlets in C. Courtesy of Dr. T.J.H. Ruigrok. Bars in B = 50 )tm, in C = 5 fim. Abbreviations a = Purkinje cell axon cp = collateral plexus.

Purkinje cells. The recurrent collaterals extend into the molecular layer where they contact basket cells (O Donoghue et al., 1989). The whole collateral arborization is oriented perpendicular to the long axis of the folia, i.e. in the same plane as the dendritic tree of the Purkinje cell. In the cat it measures 300-700 //m in the sagittal and 100 00 m in the transverse direction (Bishop, 1988). The width of the arborization and its penetration in the molecular and granular layers varies for different parts of the cerebellum. Recurrent collaterals of Purkinje cell axons are constituents of the infra- and supraganglionic plexus. The main Purkinje cell axon enters and traverses the white matter to terminate on cells of the cerebellar or the vestibular nuclei. 

Fig. 22. Localization of inositol 1,4,5-triphosphate receptor with PCD6 antibody in frozen sections of rat cerebellum by immunofluorescence. Sagittal section of the cerebellar cortex. Small arrows in the granule cell layer (GL) point to segments of immunoreactive axons which represent recurrent collaterals of Purkinje cell axons. Mignery et al. (1989).

Apart from the medial limb of the U-shaped subnucleus, the medial nucleus at this level consists of a dorsally directed tail that extends into the white matter of the posterior lobe vermis. It receives Purkinje cell axons from the vermal visual area of lobule VII (Voogd, 1964 Courville and Diakew, 1976). It constitutes one of the targets of the collateral projection from the nucleus reticularis tegmenti pontis (Gerrits and Voogd,... 

The axon of the Purkinje cell is myelinated (Fig. 9) and gives rise to recurrent collaterals (Bishop, 1982, 1988 Bishop and O Donoghue, 1986 Bishop et al., 1987 O Donoghue and Bishop, 1990). The collaterals form a plexus of beaded axons, mainly at the level of the Purkinje cell layer (Fig. 8a and b). They terminate on neighbouring... 

Bishop GA (1982) Pattern of distribution of the local axonal collaterals of Purkinje cells in the intermediate cortex of the anterior lobe and paramedian lobule of the cat cerebellum. J. Comp. Neurol, 210, 1-9. Bishop GA (1984) The origin of the reticulo-olivary projection in the rat a retrograde horseradish peroxidase... 

Bishop GA, O Donoghue DL (1986) Heterogeneity in the pattern of distribution of the axonal collaterals of Purkinje cells in zone b of the cat s vermis an intracellular HRP study. J. Comp. Neurol, 253, 483-499. Bishop GA, King JS (1986) Reticulo-olivary circuits An intracellular HRP study in the rat. Brain Res., 371, 133-145. 

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