Protein kinase C in Purkinje cells

cGMP cGMP-dependent protein kinase and nitric oxide synthase in Purkinje cells 

Immunoreactivity for guanylate cyclase, the synthesizing enzyme of cGMP, was 

Soluble guanylate cyclase is activated by nitric oxide (NO) (see Section 3.4). NO has been implicated in the generation of long term depression (LTD) of parallel fiber-mediated EPSP s in Purkinje cells. LTD can be prevented by the application of haemoglobin that absorbs NO, or by the inhibition of NO synthesis (Crepel and Jaillard, 1990 Shibuki and Okada, 1991 Ito, 1991). However, nitric oxide synthase, the synthesizing enzyme of NO, appears to be absent from the Purkinje cell (Section 3.4.). 

Isoenzymes Purkinje cells Basket stellate cells Granule cells Cerebellar nuclei 

Calmodulin-immunoreactivity was observed both in Purkinje cells and in cells of the cerebellar nuclei of the rat (Lin et al., 1980 Means and Dedman, 1980 Seto-Oshima et al., 1983, 1984). During postnatal development calmodulin-immunoreactivity was transiently present in the inner part of the external germinative layer and in fibers in the white matter of P3-P11 rat pups (Seto-Oshima et al., 1984). 

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