Purkinje cells receptors

Bergersen, L., Waerhaug, O., Helm, J. et al. A novel postsyn-aptic density protein the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Exp. Brain Res. 136 523-34,2001. 

Both anandamide and 2-AG are inactivated by enzymatic hydrolysis (Goparaju et al. 1998). Fatty acid amide hydrolase (FAAH) is an enzyme that catalyses their hydrolysis. High concentrations of FAAH were found in the cerebellum, hippocampus and neocortex of rat brain, which are also rich in cannabinoid receptors. Further, there is a complementary pattern of distribution of FAAH and the CBl receptor. For example, in the cerebellum, FAAH is found in the cell bodies of Purkinje cells and the CBl receptor is found in the axons of granule cells and basket cells, which are presynaptic to Purkinje cells. 2-AG may also be inactivated by direct esterification into membrane phospholipids. Cannabinoid Receptors... 

Taniguchi K, Shinjo K, Mizutani M, et al (1997) Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br J Pharmacol 122 809-812 Tempia F, Alojado ME, Strata P, KnOpfel T (2001) Characterization of the mGlnR(l)-mediated electrical and calcium signaling in Purkinje cells of mouse cerebellar slices. J Neurophysiol 86 1389-1397... 

Brorson J. R., Manzolillo P. A., and Miller R. J. (1994). Ca2+entry via AMPA/KA receptor and excitotoxicity in cultured cerebellar Purkinje cells. J. Neurosci. 14 187-197. 

Okubo Y., Kakizawa S., Hirose K., and lino M. (2004). Cross talk between metabotropic and ionotropic glutamate receptor- mediated signaling in parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells. J. Neurosci. 24 9513-9520. 

Tatsukawa T., Chimura T., Miyakawa H., and Yamaguchi K. (2006). Involvement of basal protein kinase C and extracellular signal-regulated kinase 1/2 activities in constitutive internalization of AMPA receptors in cerebellar Purkinje cells. J. Neurosci. 26 4820 4825. 

Haruta T, Takami N, Ohmura M et al (1997) Ca2+-dependent interaction of the growth-associated protein GAP-43 with the synaptic core complex. Biochem J 325 455-63 Harvey VL, Stephens GJ (2004) Mechanism of GABA receptor-mediated inhibition of spontaneous GABA release onto cerebellar Purkinje cells. Eur J Neurosci 20 684-700 Hata Y, Slaughter CA, Siidhof TC (1993) Synaptic vesicle fusion complex contains unc-18 homo-logue bound to syntaxin. Nature. 366 347-51... 

Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M (2002) The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells. J Neurosci 22(5) 1690-7... 

However, presynaptic NMDA autoreceptors may also mediate opposite effects, i.e., a reduction of glutamate release. At parallel fiber Purkinje cell synapses, activation of presynaptic NMDA receptors caused significant reductions in excitatory postsynaptic currents (Casado et al. 2002). Likewise, spontaneous and evoked glutamate release from the nerve endings of primary afferents in the spinal cord was reduced when presynaptic NMDA receptors were activated (Bardoni et al. 2004). In contrast to this, substance P release at such synapses was shown to be enhanced by the activation of presynaptic NMDA receptors (Liu et al. 1997). 

Duguid IC, Smart TG (2004) Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar intemeuron-Purkinje cell synapses. Nat Neurosci 7 525 Eccles JC, Kostyuk PG, Schmidt RF (1962) Central pathways responsible for depolarization of primary afferent fibres. J Physiol 161 237-57... 

Hanbauer I, Wink D, Osawa Y, Edelman GM, Gaily JA (1992) Role of nitric oxide in NMDA-evoked release of [3H]-dopamine from striatal slices. Neuroreport 3 409-12 Hartell NA (1994) cGMP acts within cerebellar Purkinje cells to produce long term depression via mechanisms involving PKC and PKG. Neuroreport 5 833-6 Haug LS, Jensen V, Hvalby O, Walaas SI, Ostvold AC (1999) Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ. J Biol Chem 274 7467-73... 

Maeshima T, Shutoh F, Hamada S, et al. Serotonin 2A receptor-like immunoreactivity in rat cerebellar Purkinje cells. Neurosci Lett 1998 252 72-74. 

---