Abnormal growth

Data suggestive of adverse developmental effects after an assumed acute oral exposure to organophosphate ester hydraulic fluids are restricted to an observation of retarded growth in calves of cows with reduced lactation, and "abnormal" growth in a calf of a cow that showed moderate ataxia, after the cows ingested grass probably contaminated with Fyrquel 150 (Beck et al. 1977). 

Disutient. Elder has been used throughout history to dissolve tumors and abnormal growths. Parts used flowers, leaves. 

Hannah RS, Roth SH. 1991. Chronic exposure to low concentrations of hydrogen sulfide produces abnormal growth in developing cerebellar Purkinje cells. Neurosci Lett 122 225-228. 

Abnormal growth factor signaling pathways lead to increased cell proliferation, suppression of apoptotic signals, and invasion contributing to metastasis. 

Hairy Leukoplakia. This is an abnormal condition of the mouth in which white plaques appear on the surfaces of the tongue. These plaques are not due to the overgrowth of a fungus or bacterium. They are due to the abnormal growth of the papillae cells of the tongue. These plaques cannot be scraped off they resemble cancer cells and appear as a result of infection with Epstein-Barr virus, which is a member of the herpes virus family. 

Bustin M, Catez F, Lim, JH (2005). The dynamics of HI function in chromatin.Mol.Celll7 617—620 Chan W-Y, Liu Q-R, Borjigin, J, Busch H, Rennert OM, Tease LA,and ChanPK(1989) Characterization of the cDNA encoding human nucleophosmin and smdies of its role in normal and abnormal growth. 

Endometriosis is abnormal growth of endometrial tissue in the peritoneal cavity. Women with this disorder have dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Danazol (Danocrine) is a 2,3-isoxazol derivative of 17a-ethynyl testosterone (ethisterone) that has weak virilizing and protein anabolic properties. It is effective in endometriosis through its negative feedback... 

Mechanism of Action A synthetic vitamin Dj analog that regulates skin cell (kerat-inocyte) production and development. Therapeutic Effect Preventing abnormal growth and production of psoriasis (abnormal kerafinocyte growth). Pharmacokinetics Minimal absorption through intact skin. Metabolized in liver. 

Results from animal studies indicate that in utero exposure to PBBs and exposure to PBBs through mothers milk can produce embryolethal effects, structural abnormalities, growth retardation, liver effects, and neurological effects in offspring. Developmental toxicity has been observed in studies with hexabromobiphenyl and octabromobiphenyl commercial mixtures, but not with commercial... 

Low activities of orotidine phosphate decarboxylase and orotate phosphoribosyltransferase result in abnormal growth, megaloblastic anemia and the excretion of large amounts of orotate in the urine. 

Thalassemia Major. Transfusion-dependem thalassemia major patients liuvc abnormal growth and sexual maturation al puberty, presumably as a result of pituitary iron overload. Still poorly understood, this disorder is reported to respond well to deferoxamine iron chelation therapy, particularly if administered before the age of maturity. 

Low activities of orotidine phosphate decarboxylase and (usually) orotate phosphoribosyltransferase are associated with a genetic disease in children that is characterized by abnormal growth, megaloblastic anemia, and the excretion of large amounts of orotate. When affected children are fed a pyrimidine nucleoside, usually uridine, the anemia decreases and the excretion of orotate diminishes. A likely explanation for the improvement is that the ingested uridine is phosphorylated to UMP, which is then converted to other pyrimidine nucleotides so that nucleic acid and protein synthesis can resume. In addition, the increased intracellular concentrations of pyrimidine nucleotides inhibit carbamoyl phosphate synthase, the first enzyme in the. naibwav of aro-tate synthesis. 

Angiotensin II also promotes abnormal growth and remodeling of the heart, and this substance is thought to be responsible for many of the pathologi-... 

Generation R The Rotterdam Study into Growth, Development and Health Study will evaluate normal and abnormal growth and development and identify biologic, social, and environmental determinants (European Commission 2004). 

The deaths of breast-fed infants in the mid-fifties in Turkey, and an epidemic of skin sores and discolorations (porphyria cutanea tarda) were associated with the accidental consumption of HCB-contaminated seed grain (refs. 93-910 Clinical symptoms included weight loss, enlargement of lymph nodes and thyroid, abnormal growth of body hair and skin photosensitization. 

Emoto, H. and Mitomo, M. Control and characterization of abnormal growth grains in silicon nitride ceramics , J. Eur. Ceram. Soc., 17 (1997) 797-804. 

It is assumed that all four manifestations of developmental toxicity (death, structural abnormalities, growth alterations, and functional deficits) are of concern. 

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