Purkinje cell bodies

Fig. 27. Immunofluorescence localization of the cerebellar Ca -ATPase in a transverse cryosection of adult chicken cerebellum. CaS/Cl-IgG localizes the Ca -ATPase to the Purkinje cell bodies in the Purkinje layer (b), and the dendritic trees in the molecular layer (a). Very faint immunofluorescence was detected in the granule cell layer (c). Bar 50 m. Kaprielian et al. (1989).

Fig. 47. Sagittal sections of the rat cerebellar cortex immuno-labelled with antibodies to GluRl (a), GluR2/3 (b,e), and GluR4 (c,d). As, astrocyte-like cells BG, Bergmann glial processes Go, Golgi cell Gr, granular layer L, Lugaro cell Mo, molecular layer Pj, Purkinje cell body WM, white matter small arrow, Purkinje cell dendrite asterisks, Bergmann glial cell body arrow head, basket/ stellate cell. Petralia and Wenthold (1992).

Figure 3. IniniMX)histoch0ndcal staining of 14 day old euthyroid ih,B) and hypothyroid (CrD) rat cerebellum with anti-Tau (A,C) and anti-MM>2 (B D) antibodies. Purkinje cell body (P) and their dendritic tree (D). Parallel fiber axons (A).

As with the vascular pathology, the most pronounced neuronal and glial effects of lead poisoning ai e seen in the cerebellum. Cerebellar weight and total cell number ai e reduced" and the size and morphology of Purkinje cell bodies cire abnormal."" " The intemeuron circuitry of the cerebellum is also altered, since the dendritic development of the Purkinje cells, which form the only efferent elements of the cerebellar cortex, is markedly disturbed by lead exposure. Press observed a decrease in the rate of Purkinje cell maturation in lead-poisoned rat pups from about 5 d onwards such that, at 10 d, the leaded cells retained more perisomatic processes than controls and the den-... 

Both anandamide and 2-AG are inactivated by enzymatic hydrolysis (Goparaju et al. 1998). Fatty acid amide hydrolase (FAAH) is an enzyme that catalyses their hydrolysis. High concentrations of FAAH were found in the cerebellum, hippocampus and neocortex of rat brain, which are also rich in cannabinoid receptors. Further, there is a complementary pattern of distribution of FAAH and the CBl receptor. For example, in the cerebellum, FAAH is found in the cell bodies of Purkinje cells and the CBl receptor is found in the axons of granule cells and basket cells, which are presynaptic to Purkinje cells. 2-AG may also be inactivated by direct esterification into membrane phospholipids. Cannabinoid Receptors... 

Schematic representation of the heart and normal cardiac electrical activity (intracellular recordings from areas indicated and ECG). Sinoatrial (SA) node, atrioventricular (AV) node, and Purkinje cells display pacemaker activity (phase 4 depolarization). The ECG is the body surface manifestation of the depolarization and repolarization waves of the heart. The P wave is generated by atrial depolarization, the QRS by ventricular muscle depolarization, and the T wave by ventricular repolarization. Thus, the PR interval is a measure of conduction time from atrium to ventricle, and the QRS duration indicates the time required for all of the ventricular cells to be activated (ie, the intraventricular conduction time). The QT interval reflects the duration of the ventricular action potential.

Purkinje cell—single layer of large cell bodies in the cerebellar cortex, between the molecular (left) and granular (right) layers. 

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