Physician

This corresponds to the physician s stethoscope case mentioned above, and has been realized [208] by bringing one leg of a resonatmg 33 kHz quartz tiinmg fork close to the surface of a sample, which is being rastered in the x-y plane. As the fork-leg nears the sample, the fork s resonant frequency and therefore its amplitude is changed by interaction with the surface. Since the behaviour of the system appears to be dependent on the gas pressure, it may be assumed that the coupling is due to hydrodynamic mteractions within the fork-air-sample gap. Since the fork tip-sample distance is approximately 200 pm -1.120), tire teclmique is sensitive to the near-field component of the scattered acoustic signal. 1 pm lateral and 10 mn vertical resolutions have been obtained by the SNAM. 

Some of the earliest studies of the aldol reaction were carried out by Aleksander Borodin Though a physician by training and a chemist by profession Borodin is re membered as the composer of some familiar works in Russian music See pp 326-327 in the April 1987 issue of the Journal of Chem ical Education for a biogra phical sketch of Borodin... 

Poiseuille was a physician-physiologist interested in the flow of blood through blood vessels in the body. Estimate the viscosity of blood from the fact that blood passes through the aorta of a healthy adult at rest at a rate of about 84 cm sec , with a pressure drop of about 0.98 mmHg m". Use 9 mm as the radius of the aorta for a typical human. 

The early USPC was dominated by physicians who selected the best dmgs. This prevented iaclusion ia the USP of a large number of substances that were widely used, particularly elixirs, a popular dosage form ia the late nineteenth ceatury. To fill this gap, ia 1888 the American Pharmaceutical Association pubUshed the first NE, which provided standards for dmgs ia wide use but aot iacluded ia the USP. A history of the Natioaal Eormulary is also iacluded at the froat of the NF sectioa ia USP XXII—NFXUII (5). 

Precautions in Handling. Ammonium bifluoride, like all soluble fluorides, is toxic if taken internally. Hydrofluoric acid bums may occur if the material comes in contact with moist skin. Ammonium bifluoride solutions should be thoroughly washed from the skin with mildly alkaline soap as soon as possible however, if contact has been prolonged, the affected areas should be soaked with 0.13% solution of Zephiran chloride, or 0.2% Hyamine 1622 (Lonza, Inc.) or calcium gluconate, the treatment recommended for hydrofluoric acid bums. If any of these solutions come in contact with the eyes, they should be washed with water for at least 10 min and a physician should be consulted. 

Potassium biduoride crystals may break down to a fine white powder that is readily airborne. In this form, the salt is quite irritating to the nasal passages, eyes, and skin. Therefore, the hands and eyes should be protected and acid dust masks should be worn while handling, as an acid duoride KHF2 can cause superficial hydroduoric acid-type bums. Areas of skin that have been in contact with potassium biduoride should be washed as soon as possible with mildly alkaline soaps or borax-containing hand cleaners. If there has been contact with the eyes, they should be washed well with water and a physician should be consulted. 

Laxatives faciUtate the passage and elimination of feces. These agents are used most commonly as self-treatment and are rarely prescribed by physicians. 

Physician s Desk Reference, 48th ed.. Medical Economics Data Production, Montvale, N.J., 1994, p. 2414. 

Immunosensors promise to become principal players ia chemical, diagnostic, and environmental analyses by the latter 1990s. Given the practical limits of immunosensors (low ppb or ng/mL to mid-pptr or pg/mL) and their portabiUty, the primary appHcation is expected to be as rapid screening devices ia noncentralized clinical laboratories, ia iatensive care faciUties, and as bedside monitors, ia physicians offices, and ia environmental and iadustrial settings (49—52). Industrial appHcations for immunosensors will also include use as the basis for automated on-line or flow-injection analysis systems to analyze and control pharmaceutical, food, and chemical processing lines (53). Immunosensors are not expected to replace laboratory-based immunoassays, but to open up new appHcations for immunoassay-based technology. 

Since diketene is a strong eye irritant even at low levels, it has a strong warning effect. Diketene becomes unbearable before acute toxic levels are reached. Due to the risk of delayed lung edema, a physician should be consulted and the patient monitored carefully after exposure. 

Workers who produce or use lead should be aware of possible ha2ards. Symptoms of chronic lead poisoning include fatigue, headache, constipation, uneasy stomach, irritabiHty, poor appetite, metallic taste, weight loss, and loss of sleep. Most of these same symptoms also occur in many common illnesses, such as the flu, thus a physician must rely on tests, such as blood lead analysis, to determine chronic lead poisoning. 

Because small children may suck on matches, the question of toxicity is often raised and the lingering, vague, though unwarranted idea of phosphoms poisoning may cause concern to laymen and even to physicians. Potassium chlorate is the only active material that can be extracted in more than traces from a match head and only 9 mg are contained in one head. This, even multiphed by the content of a whole book, is far below any toxic amount (19) for even a small child. No poisonous properties whatsoever can be imputed to the striking strip. SAW matches are similarly harmless but, because of their easy flammabihty, they should be entirely kept out of a household with smaller children. The same warning may apply to all wooden matches. 

Galen, a physician whose views outUved him by about a thousand years, died about 200 AD. He beUeved that mercurials were toxic, and did not use any mercury compound therapeutically. However, as a result of Arabian influence, the therapeutic uses of mercury were slowly recognized by Western Europe. In the thirteenth century mercury ointments were prescribed for treating chronic diseases of the skin. Mercury and its compounds, such as mercurous chloride, mercuric oxide, mercuric chloride, and mercuric sulfide, were used widely from the fifteenth to the nineteenth centuries, and to some extent in the twentieth century. During the first half of the twentieth century, the primary therapeutic uses of mercury included bactericidal preparations, such as mercuric chloride, mercuric oxycyanide, and mercuric oxide and diuretics, such as aryl HgX (Novasural) and mercurated ahyl derivatives (14). 

Protective equipment and clothing such as face shields and gloves should be worn and safety showers should be available wherever there is a possibihty of being splashed or otherwise contacted by nickel-containing solutions. If dermatitis should occur, the possibiUty that it is nickel-related should be brought to the attention of a physician. 

J. Shapiro, Rjadiation Protection A. Guide for Scientists and Physicians, 3rd ed.. Harvard University Press, Cambridge, Mass., 1990. 

The pharmacist or physician can report any problems experienced with dmg products and medical devices. In cases where the PDA and/or manufacturer finds that a marketed product constitutes an actual or potential threat to the safety and welfare of the pubhc, that product must be withdrawn from the marketplace, ie, recalled. Several classes of recalls exist, depending on the relative danger that the product exhibits. C/ass I dmgs pose a serious health threat and may require withdrawal at the consumer level C/ass II dmgs pose a possible or potential health problem that usually means withdrawal at the pharmacy or wholesaler levels and C/ass III dmgs may present a remote hazard to health and safety. 

Medical Programs. Large chemical plants have at least one hill-time physician who is at the plant five days a week and on call at all other times. Smaller plants either have part-time physicians or take injured employees to a nearby hospital or clinic by arrangement with the company compensation-insurance carrier. When part-time physicians or outside medical services are used, there is Httle opportunity for medical personnel to become familiar with plant operations or to assist in improving the health aspects of plant work. Therefore, it is essential that chemical-ha2ards manuals and procedures, which highlight symptoms and methods of treatment, be developed. A hill-time industrial physician should devote a substantial amount of time to becoming familiar with the plant, its processes, and the materials employed. Such education enables the physician to be better prepared to treat injuries and illnesses and to advise on preventive measures. 

Poly(tetramethylene ether) glycols were found to have low oral toxicity in animal tests. The approximate lethal oral dose, LD q, for Terathane 1000 has been found to be greater than 11,000 mg/kg (272). No adverse effects on inhalation have been observed. The polymer glycols are mild skin and eye irritants, and contact with skin, eyes, and clothing should be avoided. Goggles and gloves are recommended. In case of contact with the skin, wash thoroughly with water and soap. If swallowed, no specific intervention is indicated, because the compounds are not hazardous. However, a physician should be consulted (260). 

A. B. Miller, The Physician s Desk Reference, 25th ed., Litton Pubhcations, OradeU, N.J., 1971. 

Opium is the dried, powdered sap of the unripe seed pod of Papaver somniferum, a poppy plant indigenous to Asia minor. Theophrastus described its medical properties in the third century BC, but the Sumerians, ca BC 4000, probably perceived its utility. Arab physicians knew of the dmg, and Arab traders carried it to the Orient where it was used as a treatment for dysentery. Paracelsus is credited with repopularizing the dmg in western Europe in the early sixteenth century by formulating opium into "laudanum", which is still in use. More than 20 different alkaloids (qv) of two different classes comprise 25% of the weight of dry opium. The benzylisoquinolines, characterized by papaverine [58-74-2] (1.0%), a smooth muscle relaxant, and noscapine [128-62-1] (6.0%), an antitussive agent, do not have any analgesic effects. The phenanthrenes, the second group, are the more common and include 10% morphine (1, = R = H), 0.5% codeine [76-57-3], C gH2 N03, (1, R = H, R = CH3), and 0.2 thebaine [115-37-7], C 2H2 N03, (2). 

The bronchodilating effect of caffeine has been recognized for hundreds of years. In the western world the first description of a caffeine preparation for asthma was made in 1859 (59) by a Scottish physician who recommended strong black coffee as a bronchodilator. In many parts of the world, however, use of xanthines is less frequent than in the United States. 

The development of easy-to-use assays for determining theophylline blood levels afforded a handle on maintenance of effective but nontoxic levels. The relatively good availabihty of such assays in the United States probably contributed to the historical preference for theophylline treatment by U.S. physicians. Careful titration of the dose must be done on a patient-by-patient basis because individual rates of metaboHsm vary widely. Most ( 85%) of an oral dose of theophylline is metabolized by Hver microsomal enzymes. As a result many dmgs, eg, cimetidine [51481-61-9], anticonvulsants, or conditions, eg, fever, cigarette smoking, Hver disease, which affect Hver function alter theophylline blood levels. 

The advent of newer polyurethane materials is expected to lead to a new generation of cardiovascular devices. The characteristics of polyurethanes, combined with newer manufacturing techniques, should translate into direct medical benefits for the physician, the hospital, and the patient. This field offers exciting growth opportunities. 

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