Physicians’ Health Study -PHS

In a prospective nested case-control study on physicians diagnosed with Ml who were part of the Physician Health Study (PHS) (39) in the United States, plasma levels of all carotenoids (a-carotene, /3-carotene, /3-cryptoxantin, lutein, and lycopene), retinol, and a- and y-tocopherol were analyzed. No differences were noted by the physicians between the patients diagnosed with Ml and the matched controls (40),... 

This study (Physicians Health Study - PHS [10]) was a randomized, double-blind, placebo-controlled trial investigating the effects of low-dose aspirin (325 mg every other day) in 22,071 healthy male physicians in the USA. During a follow-up of 5 years there was a highly significant 44% reduction in the incidence of myocardial infarction, a slight non-significant increase in stroke (22%), and no reduction in cardiovascular mortality in subjects allocated to aspirin. 

Fig. 3. Hazard ratios of aspirin versus placebo for all cardiovascular (CV) events, all coronary (CHD) events, and all strokes in diabetic patients included in four randomized trials. ETDRS Early Treatment Diabetic Retinopathy Study PHS Physicians Health Study HOT Hypertension Optimal Treatment Study WHS Women s Health Study. References are indicated by numbers accompanying the acronyms.

ATBC, Alpha Tocopherol Beta Carotene Prevention Study CARET, Beta Carotene and Retinol Efficacy Trial LCPS, Linxian Cancer Prevention Study PHS, Physicians Health Study PPP, Primary Prevention Project SCPS, Skin Cancer Prevention Study VACP, Vitamin A and Cancer Prevention WHS, Women s Health Study CHD, Coronary Heart Disease CVD, Cardiovascular disease. 

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