Multidrug resistant

Centers for Disease Control. Nosocomial transmission of multidrug-resistant tuberenlosis among HlV-infeeted persons—Florida and New York, 1988-1991, MMWR, vol. 40, no. 34, 1991,585-591. [Pg.1011]

Juranka, P. F., Za.stawny, R. L., and Ling, V., 1989. P-Glycoprotein Multidrug-resistance and a superfamily of membrane-a.s.sociated tran.sport protein.s. The FASEByowrna/3 2583-2592. [Pg.325]

Inhibition of human multidrug resistance P-glycoprotein 1 was investigated by analogs of a potent. 5-opioid antagonist, including (35, 1 lu5)-3-[(4-hydroxy-2,6-dimethylphenyl)methyl]-11,11 u-dihydro-2//-pyrazino[l, 1-b] isoquinoline-l,4(3//,6//)-dione (OIMIIO). Opioid antagonist activity of... [Pg.324]

The unusual tolyporphin was isolated from the Pacific cyanophyte Tolypothrix nodosa and it has been shown that tolyporphin eliminates the multidrug resistance (MDR) in certain carcinoma sublines thus potentiating the cytotoxicity of anticancer drugs in these cell lines.2... [Pg.636]

ABC Transporters. Table 1 Substrates of ABC-transporters involved in multidrug resistance (MDR)... [Pg.7]

Gottesman MM, Ling V (2006) The Molecular basis of multidrug resistance in cancer tlie early years of P-glycoprotein research. FEBS Lett 580 998-1009... [Pg.8]

The breast cancer resistance protein (BCRP) belongs to the G-branch of the ABC-transporter family (ABCG2). In contrast to most other ABC-proteins, BCRP consists of only one transmembrane domain (TDM) with one nucleotide binding fold (NBF) at its C-terminus. Because of this structural characteristic BCRP as well as other ABC-transporters with only one TMD are termed half transporters. To achieve functional activity these transporters have to form hetero- or homodimers. BCRP is involved in the multidrug resistance of certain tumors and transports endogenous compounds like cholesterol and steroid hormones. [Pg.250]

Sorcin (soluble resistance-related calcium binding protein) was isolated from multidrug-resistant cells and is expressed in a few mammalian tissues such as skeletal muscle, heart, and brain. In the heart, sorcin interacts with the ryanodine receptor and L-type Ca2+-channels regulating excitation in contraction coupling. [Pg.294]

Sorcin is associated with the development of multidrug resistances in leukemia and other cancels. Sorcin is also able to improve cardiac contractility independently of (3-adienergic stimulation and may prove beneficial in treatment of heart failure. A point mutation in sorcin causes familial hypertrophic cardiomyopathy. [Pg.294]

Sheps JA, Ling V (2007) Preface the concept and consequences of multidrug resistance. Pflugers Arch 453 545-553... [Pg.752]

The multidrug resistance (MDR) phenomenon has first been described in cancer cells which were resistant against several structurally unrelated anticancer dtugs. Mechanistically a high expression of different ABC-transporters (P-gp, MRP) has been identified as the underlying factor. [Pg.793]

ABCB1 (also called MDR1) has initially been described by its ability to confer a multidrug resistance phenotype to cancer cells upon chemotherapy. This full-size... [Pg.1158]

Multidmg Resistance Multidrug Resistance Gene Multiple Sclerosis... [Pg.1497]

The phenanthroindolizidine alkaloid (-)-antofine (95) exhibits high cytotoxicity to drug-sensitive and multidrug-resistant cancer cells by arresting the G2/M phase of the cell cycle. In the first asymmetric total synthesis of (-)-95, the late-stage construction of pyrrolidine 94 for the final Pictet-Spengler cyclo-methylenation to 95 was performed by RCM and subsequent hydrogenation (Scheme 18) [67]. [Pg.288]

The multidrug resistance (mdr) reversing effect of the new phenothiazine complexes were tested on mouse T cell lymphoma cell lines. Trifluoperazine (TFP) was much more effective at the same concentration than verapamil. The efficacy of some metal coordination complexes [TFP-Cu(ll) and TFP-V(IV)] exceeded the action of TFP alone. Chlorpromazine (CPZ) or CPZ-Pt(ll) complex had the same or less effect than verapamil or promethazine (Pz) used as a control. [Pg.429]

An example of a valid, easily interpretable QSAR is that relating to P-glycoprotein-regulated multidrug resistance reversal (MDRR) by phenothi-azines [43] ... [Pg.477]

Dearden JC, AI-Noobi A, Scott AC, Thomson SA. QSAR studies on P-glycoprotein-regulated multidrug resistance and on its reversal by phenothia-zines. SAR QSAR Environ Res 2003 14 447-54. [Pg.490]

Multidrug Resistance Transporters (Efflux) (e.g. P-gp. BCRF, MRP) MoDocarboxylic Acid Transporters (Efflux) (e.g. MCTl, MCT2)... [Pg.497]

Both influx and efflux transporters are located in intestinal epithelial cells and can either increase or decrease oral absorption. Influx transporters such as human peptide transporter 1 (hPEPTl), apical sodium bile acid transporter (ASBT), and nucleoside transporters actively transport drugs that mimic their native substrates across the epithelial cell, whereas efflux transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and breast cancer resistance protein (BCRP) actively pump absorbed drugs back into the intestinal lumen. [Pg.500]

Sasaki M, Suzuki H, Aoki J, Ito K, Meier PJ and Sugiyama Y. Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2. Mol Pharmacol 2004 66 450-9. [Pg.510]

Pajeva IK and Wiese M. Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance explanation of structural variety (hypothesis). J Med Chem 2002 45 5671-5686. [Pg.511]

Langer T, Eder M, Hoffmann RD, Chiba P and Ecker GF. Lead identification for modulators of multidrug resistance based on in silico screening with a phar-macophoric feature model. Arch Pharm (Weinheim) 2004 337 317-27. [Pg.511]

Biochemical mechanisms of resistance 3.5 Multidrug resistance pumps... [Pg.181]

The advent of multidrug resistant strains of Mycobacterium tuberculosis (MDR-TB) has led to increased fears of untreatable infections by serious pathogens. Rifampicin, streptomycin and, occasionally, the quinolones are drugs used in the treatment of mycobacterial infections and resistance to those agents is as described previously. There... [Pg.196]

Cohen S.P., Yan W. Levy S.B. (1993) A multidrug resistance regulatory locus is widespread among enteric bacteria. J Infect Dis, 168, 484-488. [Pg.200]

George AM. (1996) Multidrug resistance in enteric and other Gram-negative bacteria. FEMSMicrobiol Lett, 139, 1-10. [Pg.200]

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