Vitro Models and Multidrug Resistance Mechanisms of the Placental Barrier

In Vitro Models and Multidrug Resistance Mechanisms of the Placental Barrier 

Keywords Placenta Trophoblast Multidrug resistance Transport Cell culture 

MDCKII Madin-Darby canine kidney strain II 

PPARa Peroxisome proliferators-activated receptor type alpha 

The human placenta expresses a number of nutrient and efflux transporters, as well as metabolic enzymes. Information about the placental function and regulation of these systems, and how they interact with the administered drug, can help to target them appropriately so as to limit fetal exposure to harmful substances. 

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