Proteins calcium-binding

MRC Group in Protein Structure and Function Department of Biochemistry, [Pg.105]

In our laboratory, we have developed a new protocol for isolating four calcium binding proteins from smooth muscle. These include 67-kDa calcium binding protein (67 calcimedin), calmodulin, 12-kDa calcium [Pg.105]

Copyright 1996 by Academic Press, Inc. All rights of reproduction in any form reserved. [Pg.105]

FIGURE 1 Elution profile of calcium binding proteins from a DEAE-cellulose column. Solvent system used was 20 mM imidazole (pH 6.2), 1 mM EDTA, containing 1000 ml of a linear NaCl gradient from 0 to 0.25 M. Reprinted with permission from Biochemistry (29). Copyright 1990 American Chemical Society. [Pg.106]

12-kDa CaBP could easily be separated from 35-kDa calcimedin on an Ultragel AcA44 gel filtration column [Pg.106]

Fig. 2. Homeostatic control of blood Ca " level where PTH is parathyroid hormone [9002-64-6], CC, cholecalciferol, ie, vitamin D HCC, hydroxycholecalciferol DHCC, dihydroxycholecalciferol CaBP, calcium-binding protein NAD PH, protonated nicotinarnide-adenine dinucleotide...

Calcium is absorbed from the intestine by facilitated diffusion and active transport. In the former, Ca " moves from the mucosal to the serosal compartments along a concentration gradient. The active transport system requires a cation pump. In both processes, a calcium-binding protein (CaBP) is thought to be required for the transport. Synthesis of CaBP is activated by 1,25-DHCC. In the active transport, release of Ca " from the mucosal cell into... [Pg.376]

Calcium-binding protein is not found in the intestinal mucosa of vitamin D-deficient animals. It is synthesized only in response to the presence of a material with vitamin D activity. Thus, using antisemm specific to intestinal calcium-binding protein, a radioimmunodiffusion assay (98) conducted on ... [Pg.133]

Nonrepetitive but well-defined structures of this type form many important features of enzyme active sites. In some cases, a particular arrangement of coil structure providing a specific type of functional site recurs in several functionally related proteins. The peptide loop that binds iron-sulfur clusters in both ferredoxin and high potential iron protein is one example. Another is the central loop portion of the E—F hand structure that binds a calcium ion in several calcium-binding proteins, including calmodulin, carp parvalbumin, troponin C, and the intestinal calcium-binding protein. This loop, shown in Figure 6.26, connects two short a-helices. The calcium ion nestles into the pocket formed by this structure. [Pg.182]

Two types of stabilized coelenterazine are known to exist in biolu-minescent organisms, i.e. the protein-bound form (usually bound to a calcium-binding protein) and the enol ester form (usually enol-sulfate see Structure I, Fig. 5.5). [Pg.365]

Cormier, M. J., and Charbonneau, H. (1977). Isolation, properties and function of a calcium-triggered luciferin binding protein. In Wasserman, R. H., et al. (eds.), Calcium Binding Proteins and Calcium Function, pp. 481-489. Elsevier North-Holland. [Pg.388]

Inouye, S., et al. (1989). Overexpression and purification of the recombinant calcium-binding protein, apoaequorin./. Biochem. 105 473-477. [Pg.406]

Prasher, D., McCann, R. O., and Cormier, M. J. (1985). Cloning and expression of the cDNA coding for aequorin, a bioluminescent calcium-binding protein. Biochem. Biophys. Res. Commun. 126 1259-1268. [Pg.427]

CAPL (S100A4) Calcium-binding protein Decrease of in vitro invasion reduction in expression of MMP-2, MT1-MMP, and TIM P-1 decrease of in vivo metastatic ability... [Pg.187]

These calcium-binding proteins form a superfamily of proteins containing more than 600 members [1-3]. The... [Pg.291]

Sorcin (soluble resistance-related calcium binding protein) was isolated from multidrug-resistant cells and is expressed in a few mammalian tissues such as skeletal muscle, heart, and brain. In the heart, sorcin interacts with the ryanodine receptor and L-type Ca2+-channels regulating excitation in contraction coupling. [Pg.294]

ALG-2 is the fust calcium-binding protein of the EF-hand family found to be directly involved in apoptosis. ALG-2 is a 22 kDa protein and like the other members of the penta EF-hand family, contains five EF-hands, with only two of them functional. ALG-2 protein is expressed in the brain and eye and was found to be upregulated in various cancer tissues. Several targets have been found, such as proteins AEP, Alix, preflin, and annexins, suggesting a putative role of ALG-2 in apoptosis. [Pg.294]

Krebs J, Heizmann CW (2007) Calcium-binding proteins and the EF-hand principle. In Krebs J, Michalak M (eds) Calcium a matter of life and death, New Comprehensive Biochemistry, vol 41 (Series Bernardi G). Elsevier, pp 51-93... [Pg.295]

Small ubiquitous calcium-binding protein. Calmodulin binds and regulates the activity of many protein targets involved in cellular signal transduction pathways mediated by calcium. Calmodulin is ranked among the most conserved proteins and plays a key role in many cellular processes. [Pg.311]

S100A1 S100 calcium binding protein A1 S100A, S 100-alpha 1q21 NM 006271... [Pg.1102]

S100A2 S100 calcium binding protein A2 S100L, CaN19 1q21 NM 005978... [Pg.1102]

S100A3 S100 calcium binding protein A3 S100E 1q21 NM 002960... [Pg.1102]

S100A5 S100 calcium binding protein A5 S100D 1q21 NM 002962... [Pg.1102]

S100A6 S100 calcium binding protein A6 Calcydin (CACY), 2A9, PRA, CABP 1q21 NM 014624... [Pg.1102]

S100A7 S100 calcium binding protein A7 Psoriasin 1 (PSOR1), S100A7c 1q21 NM 002963... [Pg.1102]

S100A7A S100 calcium binding protein A7A S100A15, S100A7L1 1q21 NM 176823... [Pg.1102]

S100A7L2 S100 calcium binding protein A7-like 2 S100A7b 1q21 —... [Pg.1102]

S100A7P1 S100 calcium binding protein A7 pseudogene 1 S100A7L3, S100A7d 1q21 ... [Pg.1102]

S100A11 S100 calcium binding protein A11 Calgizzarin, S100C 1q21 NM 005620... [Pg.1102]

S100A11P S100 calcium binding protein A11 pseudogene S100A14 7q22-q31 ... [Pg.1102]

S100A13 S100 calcium binding protein A13 1q21 NM 005979... [Pg.1102]

S100A14 S100 calcium binding protein A14 BCMP84, S100A15 1q21 NM 020672... [Pg.1102]

S100A16 S100 calcium binding protein A16 S100F, DT1P1A7, MGC17528 1q21 NM 080388... [Pg.1102]

S100B S100 calcium binding protein B S 100-beta 21q22 NM 006272... [Pg.1102]

S100G S100 calcium binding protein G Calbindin 3 (CALB3), CaBP9K, CABP1 Xp22 NM 004057... [Pg.1102]

S100P S100 calcium binding protein P 4p16 NM 005980... [Pg.1103]

S100Z S100 calcium binding protein Z S100-zeta 5q13 NM 130772... [Pg.1103]

Calcium-binding proteins. F. L. Siegel, Struct. Bonding (Berlin), 1973,17, 221-268 (209). [Pg.43]

Calcium-binding proteins, 6, 564, 572, 596 intestinal, 6, 576 structure, 6, 573 Calcium carbonate calcium deposition as, 6, 597 Calcium complexes acetylacetone, 2, 372 amides, 2,164 amino acids, 3, 33 arsine oxides, 3, 9 biology, 6, 549 bipyridyl, 3, 13 crown ethers, 3, 39 dimethylphthalate, 3, 16 enzyme stabilization, 6, 549 hydrates, 3, 7 ionophores, 3, 66 malonic acid, 2, 444 peptides, 3, 33 phosphines, 3, 9 phthalocyanines, 2,863 porphyrins, 2, 820 proteins, 2, 770 pyridine oxide, 3,9 Schiff bases, 3, 29 urea, 3, 9... [Pg.97]

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