Multidrug-resistant tuberculosis MDR-TB

Isoniazid and rifampin are the two most important tuberculosis drugs organisms resistant to both these drugs [multidrug-resistant tuberculosis (MDR-TB)] are much more difficult to treat. 

World Health Organization. (2006b). Drug- and multidrug-resistant tuberculosis (MDR-TB)—Frequently asked questions. Retrieved March 27, 2007 from http //www.who.int/ tb/dots/dotsplus/faq/en/index.html... 

Multidrug-resistant tuberculosis (MDR-TB) is defined as resistance to two or more drugs. Risk factors include living in an area of over 4% INH resistance recent immigration from Asia or Latin America and a histoiy of treatment of tuberculosis without rifampin. 

Prevention C. for D.C. and. 2012. Fact Sheets Multidrug-Resistant Tuberculosis (MDR TB). URL < http //www.cdc.gov/tb/puhlications/factsheets/drth/mdrth.htm >. 

Multidrug-resistant tuberculosis (MDR-TB) no longer can be cured by the leading TB antibiotics isoniazid (2) and rifampicin (3). Extensively drug-resistant TB (XDR-TB) is a form of TB caused by organisms that are resistant to isoniazid (2) and rifampicin (3), as well as fluoroquinolones such as ciprofloxacin (7), and ofloxacin (8) and any of the second-line anti-TB injectable drugs such as amikacin, kanamycin, or capreomycin. 

The advent of multidrug resistant strains of Mycobacterium tuberculosis (MDR-TB) has led to increased fears of untreatable infections by serious pathogens. Rifampicin, streptomycin and, occasionally, the quinolones are drugs used in the treatment of mycobacterial infections and resistance to those agents is as described previously. There... 

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