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Resistance, antimalarials multidrug

Since that time, artemisinin has been used successfully in many thousand malaria patients throughout the world including those infected with both cldoroquine-sensitive and chloroquine-resistant strains of P falciparum. Artemisinin has progressively estabhshed itself as one of the most potent and effective antimalarial dmg, and is primarily recommended in the treatment of multidrug-resistant strains of P. falciparum. However, the therapeutic... [Pg.242]

Artemisia annua L. A. apiacea Hance ex Walpers Qing Guo (Stinking artemisia) (aerial part) Dihydroartemisinin, artesunate, artemisinin, chloroquine, flavonoids, sesquiterpene.33-269-476 This herb is mildly toxic. A schizonticidal agent, antimalarial, treat infections of multidrug-resistant strains of Plasmodium falciparum, the cause of human malignant cerebral malaria. [Pg.34]

Vinyl-l,2,4-Trioxyspiro antimalarial agents, (I), prepared by Singh (2) were effective in treating multidrug-resistant malaria strains. [Pg.434]

McGready R, Cho T, Keo NK, Thwai KL, Villegas L, Looareesuwan S, White NJ, Nosten F. Artemisinin antimalarials in pregnancy a prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum. Clin Infect Dis 2001 33(12) 2009-16. [Pg.347]

Multidrug resistance is a serious impediment to improved healthcare. Multidrug resistance is most frequently due to active transporters, such as the P-glycoprotein (ABCBl) identified 30 years ago, that pump a broad spectrum of chemically distinct molecules out of the cells, including antibiotics, antimalarials and cancer chemotherapeutics in humans. ... [Pg.89]

Mefloquine (133) was developed during the Vietnam war, during a programme to find new antimalarials, to protect American soldiers from the multidrug resistant P. falciparum infection. The Walter Reed Army Institute for Research started preclinical development of mefloquine in 1972, filed and started human studies in the same year. After a successful evaluation of the drug potential further... [Pg.838]

Lumefantrine is a derivative of halofantrine that has been reported to exhibit antimalarial activity when combined with artemether in the treatment of multidrug-resistant Plasmodium falciparium. No evidence of cardiotoxicity has been reported with this combination, which may offer promise for successful treatment of resistant organisms. [Pg.1688]

Artemisinin 337 is a natural efficient antimalarial drug for the treatment of multidrug-resistant forms of P. falciparum. However, pharmacological problems associated with 337, especially a short plasma half-life prompted scientists to search for more metabolically stable derivative. 10-Triiluoromethyl artemisinin 338 was shown to have improved stability. ... [Pg.482]

See other pages where Resistance, antimalarials multidrug is mentioned: [Pg.4]    [Pg.239]    [Pg.243]    [Pg.255]    [Pg.257]    [Pg.4]    [Pg.133]    [Pg.133]    [Pg.349]    [Pg.351]    [Pg.363]    [Pg.369]    [Pg.128]    [Pg.163]    [Pg.225]    [Pg.157]    [Pg.343]    [Pg.142]    [Pg.154]    [Pg.168]    [Pg.199]    [Pg.11]    [Pg.390]    [Pg.521]    [Pg.20]    [Pg.547]    [Pg.289]    [Pg.299]    [Pg.332]    [Pg.783]    [Pg.674]    [Pg.679]    [Pg.680]    [Pg.36]    [Pg.185]    [Pg.390]    [Pg.269]    [Pg.276]    [Pg.187]    [Pg.628]    [Pg.2960]    [Pg.3531]   
See also in sourсe #XX -- [ Pg.556 ]



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Multidrug-resistant

Resistance, antimalarials

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