Ryanodine receptors

Sorcin (soluble resistance-related calcium binding protein) was isolated from multidrug-resistant cells and is expressed in a few mammalian tissues such as skeletal muscle, heart, and brain. In the heart, sorcin interacts with the ryanodine receptor and L-type Ca2+-channels regulating excitation in contraction coupling. [Pg.294]

A regenerative process whereby an intracellular Ca2+ channel (IP3 receptor or Ryanodine receptor) is itself stimulated by Ca2+, allowing thereby Ca2+ to promote its own release from intracellular stores. [Pg.300]

Ca2+ sparks are localized and transient Ca2+ release observed recurrently in muscle cells and skinned fibres. A Ca2+ spark is considered to be the elementary process of Ca2+ release in situ from one to a few ryanodine receptors. [Pg.305]

IP3 Receptor Ryanodine Receptor Non-selective Cations Channels TRP Channels... [Pg.306]

Local and transient Ca2+ increases that propagate throughout the cytosol of individual cells in the form of waves. Ca2+ waves are generated by a positive feedback activation of Ca2+ release from the intracellular Ca2+ stores through ryanodine receptors or inositol IP3 receptors. [Pg.306]

Calsequestrin is the major calcium storage protein of the sarcoplasmic reticulum in skeletal and cardiac muscles. It is highly acidic and has a large capacity for Ca2+. Calsequestrin functions to localize calcium near the junctional face of the terminal cistemae from which calcium can be released into the cytosol via the ryanodine receptor. [Pg.314]

Inwardly Rectifying K+ Channels ATP-dependent K+ Channels Voltage-dependent Ca2+ Channels Ryanodine Receptor Voltage-dependent Na2+ Channels... [Pg.347]

Voltage-dependent Ca2+ Channels Ca2+ Channel Blockers Ryanodine Receptor... [Pg.427]

Malignant hyperthermia (MH) is an autosomal-dominant pharmacogenetic disorder that is triggered by exposure to inhalation of general anesthetics, such as halothane. In susceptible individuals, these drugs can induce tachycardia, a greatly increased body metabolism, muscle contracture and an elevated body temperature (above 40°C) with a rapid rate of increase. Many cases of MH are linked to a gene for type 1 ryanodine receptor (RyRl). [Pg.740]

Ryanodine receptor (RyR) is an intracellular Ca2+ release channel in the sarcoplasmic reticulum (SR) or the endoplasmic reticulum (ER). RyR binds ryanodine (a plant alkaloid, see Drugs) with a high affinity, after which it is named. [Pg.1095]

Ryanodine Receptor. Table 1 Three Mammalian RyR isoforms... [Pg.1096]

Ryanodine Receptor. Figure 1 Three-dimensional architecture of the RyR1 by cryo-electron microscopy, (a), top view (from the T-tubule) (b), bottom view (from the SR lumen) (c), side view (parallel to the SR membrane). The binding sites of FKBP12, apo-CaM and Ca -CaM are indicated in the side view. Courtesy of Dr. M. Samso (modified from Samso etal. (2005) Nat Struct Mol Biol 12 539-544). [Pg.1096]

Fill M, Copello JA (2002) Ryanodine receptor calcium release channels. Physiol Rev 82 893-922... [Pg.1099]

Franzini-Armstrong C, Protasi F (1997) Ryanodine receptor of striated muscles a complex channel capable of multiple interactions. Physiol Rev 77 699-672... [Pg.1099]

Ogawa Y, Kurebayashi N, Murayama T (1999) Ryanodine receptor isoforms in excitation-contraction coupling. Adv Biophys 36 27-64... [Pg.1099]

S100A1 is the most abundant in the myocardium but is also expressed in brain and other tissues. S100A1 was found to stimulate Ca2+-induced Ca2+-release (CICR) in skeletal muscle terminal cisternae. In the presence of nanomolar Ca2+-concentrations, S100A1 binds to the ryanodine receptor increasing its channel open probability, and was shown to enhance SR Ca2+-release and contractile performance. Several animal models (over expressing S100A1 or S100A1-deficient mice) have... [Pg.1104]

Sarcoplasmic reticulum (SR) is a form of the smoothfaced endoplasmic reticulum (ER) in muscles. It functions as an intracellular Ca2+ store for muscle contraction. Ca2+ is energetically sequestered into the SR by Ca2+-pump/sarcoplasmic endoplasmic reticulum Ca2+-ATPase (SERCA) and released via Ca2+ release channels on stimuli (ryanodine receptor in striated muscles and inositol 1,4,5-trisphosphate receptor in most smooth muscles). Endoplasmic reticulum in non-muscle tissues also functions as an intracellular Ca2+ store. [Pg.1110]

In striated muscles, SR is well developed to surround the myofibrils and is divided into two parts, the terminal cisternae (TC) and longitudinal tubules (LT). TC forms triad (skeletal muscle) or dyad (heart) structure with transverse tubules. The ryanodine receptor is located only in the TC, whereas the Ca2+ pump/SERCA is densely packed in both TC and LT. [Pg.1110]

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