P-glycoprotein multidrug

Juranka, P. F., Za.stawny, R. L., and Ling, V., 1989. P-Glycoprotein Multidrug-resistance and a superfamily of membrane-a.s.sociated tran.sport protein.s. The FASEByowrna/3 2583-2592. [Pg.325]

Pajeva IK and Wiese M. Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance explanation of structural variety (hypothesis). J Med Chem 2002 45 5671-5686. [Pg.511]

Romsicki, Y., Sharom, F. J., Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter, Biochemistry 2001, 40, 6937-6947. [Pg.488]

Keywords Blood-brain barrier P-glycoprotein Multidrug resistance-associated protein Capillaries Endothelial cells Pregnane X receptor... [Pg.397]

Brooks T, Minderman H, O Loughlin KL, Pera P, Ojima 1, Baer MR, Bemacki RJ. (2003) Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Mol Cancer Ther 2 1195-1205. [Pg.169]

The bihary and renal excretion of some drugs (e.g., anthracyclines, vinca alkaloids, dactinomycin, etopo-side) by the P-glycoprotein multidrug transporter can be inhibited by other drugs that are also transported by P-glycoprotein. [Pg.635]

Matsuoka, Y., et al. 1999. Developmental expression of P-glycoprotein (multidrug resistance gene product) in rat brain. J Neurobiol 39 383. [Pg.592]

Teft WA et al (2011) Endoxifen, the active metabolite of tamoxifen, is a substrate of the efflux transporter P-glycoprotein (multidrug resistance 1). Drug Metab Dispos 39 558-562... [Pg.248]

Juranka PF, Zastawny RL, Ling V. P-glycoprotein multidrug-resistance and a superfamily of membrane-associated transport proteins. FASEB J 1989 3(14) 2583-2592. [Pg.409]

Fardel O, Lecureur V, Guillouzo A. The P-glycoprotein multidrug transporter. Gen Pharmacol 1996 27(8) 1283-1291. [Pg.409]

Romsicki Y, Sharom FJ. The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry 1999 38 (21) 6887-6896. [Pg.419]

Romsicki Y, Sharom FJ (1999) The mebrane lipid environment modulates drug interactions with P-glycoprotein multidrug transporter. Biochemistry 38 6887-6896 Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J (2003) Comparison of in vitro P-glycoprotein screening assays recommendations for their use in drug discovery. J Med Chem 46(9) 1716—1725... [Pg.453]

Eckford PD, Sharom FJ (2005) The reconstituted P-glycoprotein multidrug transporter is a flip-pase for glucosylceramide and other simple glycosphingolipids. Biochem J 389 517-526... [Pg.1689]

Key Words P-glycoprotein, multidrug-resistance proteins, transferrin receptor, scavenger receptors, large amino acid transporters, nucleoside transporters, anion transporters... [Pg.629]

Liu, R., Siemiarczuk, A., and Sharom, F.J. (2000) Intrinsic fluorescence of the P-glycoprotein multidrug transporter sensitivity of tryptophan residues to binding of drugs and nucleotides. Biochemistry, 39 (48), 14927-14938,... [Pg.43]

Sisodiya, S.M. et al. (2006) Vascular colocalization of P-glycoprotein, multidrug-resistance associated protein 1, breast cancer resistance protein and major vault protein in human epileptogenic pathologies. [Pg.408]

P-glycoprotein multidrug trausporter (P-gp) ou drug absorp-tiou has beeu studied exteusively. Siuce P-gp is located ou the epithelium of iutestiual cells, it cau act as a couuter-trausport pump that trausports its substrates back iuto the iutestiual lumeu as they begiu to be absorbed across the iutestiual wall. [Pg.643]

See, for example, Andrivon, W., et ai. A new anthracycline with potent anti-leukemic activity overcomes P-glycoprotein multidrug resistance. Leuk. Res. 1998, 22, 719-725. [Pg.428]

Yeh JJ, Hsu NY, Hsu WH, Tsai CH, Lin CC and Liang JA. Comparison of chemotherapy response with P-glycoprotein, multidrug resistance-related protein-1, and lung resistance-related protein expression in untreated small cell lung cancer. Ltmg 2005 183 177-183. [Pg.637]

P-glycoprotein multidrug transporter (P-gp) on drug absorption has been studied extensively. Since P-gp is located on the epithelium of intestinal cells, it can act as a countertransport pump that transports its substrates back into the intestinal lumen as they begin to be absorbed across the intestinal wall. [Pg.643]

Involved in P-Glycoprotein Multidrug Resistance Explanation of Structural Variety (Hypothesis). [Pg.403]

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