Multidrug-resistant organisms

Vancomycin is a glycopeptide antibiotic that is very important in human medicine because of its activity against multidrug-resistant organisms such as MRSA and enterococci. Vancomycin is only active against Gram-positive bacteria. In recent years, nosocomial infections of vancomycin-resistant enterococci (VRE) have become a major problem in human hospitals. Recently, a MRSA... 

Guideline-Management of Multidrug-Resistant Organisms in Healthcare Settings (2006) Public Reporting of Healthcare-Associated Infections (2005)... 

Sasaki M, Suzuki H, Aoki J, Ito K, Meier PJ and Sugiyama Y. Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2. Mol Pharmacol 2004 66 450-9. 

Isoniazid and rifampin are the two most important tuberculosis drugs organisms resistant to both these drugs [multidrug-resistant tuberculosis (MDR-TB)] are much more difficult to treat. 

Organic anion transporters can be divided into three major families organic anion transporters (OATs), organic anion transporting polypeptides (OATPs), and multidrug resistance associated proteins (MRPs) [201]. 

A rational approach to problems such as drug targeting to regions protected by P-gp, inhibition or even prevention of multidrug resistance in different organisms, and prediction of drug-drug interactions due to P-gp should become possible with reliable structure-activity relationship (SAR) studies. 

Zeng H, Bain LJ, Belinsky MG, Kruh GD. Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kid-... 

Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F et al. Multidrug-resistance protein 5 is a multi-specific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 2000 97( 13) 7476-7481. 

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