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Multidrug resistance effect

The multidrug resistance (mdr) reversing effect of the new phenothiazine complexes were tested on mouse T cell lymphoma cell lines. Trifluoperazine (TFP) was much more effective at the same concentration than verapamil. The efficacy of some metal coordination complexes [TFP-Cu(ll) and TFP-V(IV)] exceeded the action of TFP alone. Chlorpromazine (CPZ) or CPZ-Pt(ll) complex had the same or less effect than verapamil or promethazine (Pz) used as a control. [Pg.429]

Some metabolites of curcumin (particularly tetrahydrocurcumin) may also participate in producing the observed effects of curcumin in different models because these metabolites display greater stabilities than the parent curcumin molecule at physiological pH. Recent data show similar modes of action of curcumin metabolites regarding antioxidant enzyme induction and inhibition of multidrug-resistant proteins. " Additional data indicate that curcumin may even act against other types of diseases such as atherosclerosis " " and Alzheimer s disease. " - " ... [Pg.139]

J. P., Atassi, G., Effects of a new triazinoaminopiperidine derivative on adriamydn accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance, Biochem. Pharmacol. 1992, 44, 1707-1715. [Pg.442]

Cytostatic drugs for which inhibitors are primarily needed are often not only substrates of P-gp but also inducers of P-gp overexpression with one or even several type II units. An important point to clarify would be whether or not type II units are required to achieve a cytostatic effect. If they were not required, it might be possible to eliminate the P-gp-inducing effect that causes multidrug resistance by eliminating type II units. So far, the only other possibility of overcoming multidrug resistance is to inhibit the transporters involved. Inhibition can be achieved essentially by two different concepts ... [Pg.486]

As described in several monographs [4], bryostatin 1 exhibits significant in vitro and in vivo antineoplastic activity against a range of tumor cell lines including murine leukemia, B-cell lymphoma, reticulum cell sarcoma, ovarian carcinoma, and melanoma. It is also effective in the modulation of apoptotic function [5], the reversal of multidrug resistance [6], and stimulation of the immune system [7]. These unique features displayed by bryostatin 1 are attributed to its high affinity for protein kinase C (PKC) isozymes and its ability to selectively modulate their functions [8]. PKCs are a type of intracellular serine and threonine kinase that... [Pg.104]

Fluoroquinolones such as ciprofloxacin (500 mg orally twice daily for 10 days in adults) are the drugs of choice for enteric fever, particularly in areas where multidrug resistance is common. A short course of 3 to 5 days is effective but a minimum of 10 days is recommended in severe cases. [Pg.445]

Li J, Xu LZ, Yao JJ, Guo WJ, Xia P, Chen Y (2001a) Reversal effects of droloxifene on multidrug resistance in adriamycin-resistant K562 cell line. Acta Pharmacol Sin 22(11) 1023—1027... [Pg.112]

Multidentate V-heterocyclic ligands, thorium and, 24 767 Multidimensional gas chromatography, 4 617-618 6 433-434 Multidrug resistant bacteria, 18 252 Multi-effect distillation (ME), 26 65—67 Multi-effect vapor-compression submerged-tube desalination plant, 26 70 Multielevation piperacks, 19 515 Multifeed fractionation, 10 616 Multifilamentary superconductor, 23 846 Multifilament sutures, 24 218 threads for, 24 207 Multifilament yarns, 11 177-178 Multifile patent searches, 18 244 Multifunctional aliphatic epoxies, 10 376 Multifunctional coatings, 1 714-716 Multifunctional epoxy resins, 10 367-373, 418, 454... [Pg.605]

Grzywacz, M.J., Yang, J.M. and Hait, W. N. (2003) Effect of the multidrug resistance protein on the transport of the antiandrogen flutamide. Cancer Research, 63, 2492-2498. [Pg.359]

Yamazaki, M., Li, B., Louie, S.W., Pudvah, N.T., Stocco, R., Wong, W., Abramovitz, M., Demartis, A., Laufer, R., Hochman, J.H., Prueksaritanont, T. and Lin, J.H. (2005) Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport. Xenobiotica, 35, 737-753. [Pg.361]

J. (2003) Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. Pharmacogenetics, 13, 651-660. [Pg.364]

Lo Y-L (2003) Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. J Control Release 90 37 -8... [Pg.451]

Lavie, Y., Harel-Orbital, T., Gaffield, W. and Liscovitch, M. (2001). Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human breast cancer cells. Anticancer Res., 21, 1189-1194. [Pg.68]

Since that time, artemisinin has been used successfully in many thousand malaria patients throughout the world including those infected with both cldoroquine-sensitive and chloroquine-resistant strains of P falciparum. Artemisinin has progressively estabhshed itself as one of the most potent and effective antimalarial dmg, and is primarily recommended in the treatment of multidrug-resistant strains of P. falciparum. However, the therapeutic... [Pg.242]

See other pages where Multidrug resistance effect is mentioned: [Pg.390]    [Pg.390]    [Pg.445]    [Pg.440]    [Pg.89]    [Pg.503]    [Pg.139]    [Pg.1110]    [Pg.135]    [Pg.475]    [Pg.498]    [Pg.4]    [Pg.60]    [Pg.96]    [Pg.98]    [Pg.286]    [Pg.172]    [Pg.173]    [Pg.188]    [Pg.23]    [Pg.226]    [Pg.367]    [Pg.27]    [Pg.28]    [Pg.143]    [Pg.371]    [Pg.379]    [Pg.403]    [Pg.272]    [Pg.176]    [Pg.245]    [Pg.658]    [Pg.239]    [Pg.243]    [Pg.455]    [Pg.196]    [Pg.147]   
See also in sourсe #XX -- [ Pg.390 ]



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Multidrug-resistant

Resistance effects

Resistant effects

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