Transporter multidrug resistance

Multidrug Resistance Transporters (Efflux) (e.g. P-gp. BCRF, MRP) MoDocarboxylic Acid Transporters (Efflux) (e.g. MCTl, MCT2)... 

Doyle LA, Yang W, Abruzzo LV, Krog-mann T, Gao Y, Rishi AK et al. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 1998 95(26) 15665-15670. 

Gottesman, M.M., Ambudkar, S.V., Cornwell, M.M., Pastan, I. and Germann, U.A. (1996) Multidrug resistance transporter, in Molecular Biology of Membrane Transport Disorders, (ed. S.G. Schultz), Plenum Press, New York, NY, pp.243-257. 

J. (2003) Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. Pharmacogenetics, 13, 651-660. 

Hollo, Z., Homolya, L., Davis, C.W. and Sarkadi, B. (1994) Calcein accumulation as a fluorometric functional assay of the multidrug resistance transporter. Biochimica et Biophysica Acta, 1191, 384-388. 

Keywords Placenta Trophoblast Multidrug resistance Transport Cell culture... 

Fellay J, Marzolini C, Meaden E, Back D, Buclin T, Chave J, Decosterd LA, Furrer H, Opravil M, Pantaleo G, Retelska D, Ruiz L, Schinkel AH, Vernazza P, Eap CB, Telenti A. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1 a pharmacogenetics study. Lancet 2002 359 30-36. 

A large number of plant compounds interact with the ATP-dependent, multidrug resistance transporter (MDR transporter or P glycoprotein transporter). This belongs to the ATP-binding cassette family of solute transporters (ABC transporters) and functions to remove unwanted chemicals of xenobiotic origin (notably compounds from plants). 

Goffeau A, et al. Multidrug-resistant transport proteins in yeast complete inventory and phylogenetic characterization of yeast 28. open reading frames with the major facilitator superfamily. Yeast 1997 13 43-54. 

Gottesman MM, Ambudkar SV, Corn-well MM, Pastan I, Germann UA. 1996. Multidrug resistance transporter. 

Annamycin, a semi-synthetic lipophilic doxorubicin analogue, capable of circumventing multidrug-resistance transporters, was incorporated in tween-containing liposomes. (34-36). Currently, this liposomal formulation is investigated in Phase II trials in patients with refractory or relapsed acute lymphocytic leukemia (37). 

MTX is actively transported into the cell by solute carrier 19A1 (SLC 19A1), also called reduced folate carrier 1 (RFC1) (Fig. 1). MTX is pumped out of the cell by members of the ATP binding cassette (ABC) family of transporters, also known as multidrug resistant transporters (MDRs), and multidrug resistance-associated... 

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