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Tolypothrix nodosa

The unusual tolyporphin was isolated from the Pacific cyanophyte Tolypothrix nodosa and it has been shown that tolyporphin eliminates the multidrug resistance (MDR) in certain carcinoma sublines thus potentiating the cytotoxicity of anticancer drugs in these cell lines.2... [Pg.636]

Tolyporphyrin A from the microalga Tolypothrix nodosa reverses multidrug resistance in a Vinblastine-resistant population of human ovarian adenocarcinoma cells. In a synthesis of Tolyporphin A, four 0-benzyl groups were cleaved from the C-glycoside rings of 150.1 [Scheme 4.150] using zinc chloride and ethane-... [Pg.254]

Tolypodiol (13) is a meroditerpene that was isolated from a cultured sample of Tolypothrix nodosa originally collected in a soil sample from Nan Madol, Pohnpei. Its structure was determined by a combination of mass spectral analysis and NMR of the parent compound as well as its acetylated analogue. Tolypodiol was found to possess anti-inflammatory activity in the mouse ear edema assay with an ED50 = 30 pg per ear, which rivals that of the standard, hydrocortisone (20 pg per ear). ... [Pg.153]

The only representative of this class of compounds that is not involved in bacterial photosynthesis is the recently discovered tolyporphin 20. The unusual tolyporphin occurs in the Pacific cyanophyte tolypothrix nodosa. The substitution pattern, especially the tetrahydropyran moieties of the bacteriochlorin, is unique among naturally occurring... [Pg.5]

Fig. 7 Tolyporphins B-F, K found in lipophilic extracts of blue-green alga Tolypothrix nodosa... Fig. 7 Tolyporphins B-F, K found in lipophilic extracts of blue-green alga Tolypothrix nodosa...
Occurrence T. A and several closely related T. were isolated from the Pacific alga Tolypothrix nodosa. T. A is able to break the resistance of cancer cells, directed concomitantly against several anticancer drugs [mul-... [Pg.656]

The only naturally occurring bacteriochlorin that is not involved in photosynthesis is the tolyporphin 131 isolated by Prinsep et from the blue-green alga Tolypothrix nodosa. This compound, which enhances the cytotoxicity of adriamycin or vinblastine in SK-VLB cells at doses as low as 1 pg/ml, is characterized as a multidrug resistance-... [Pg.183]

Prinsep MR, Patterson GML, Larsen LK, Smith CD (1995) Further Tolyporphins from the Blue-Green Alga Tolypothrix nodosa. Tetrahedron 51 10523... [Pg.43]

See other pages where Tolypothrix nodosa is mentioned: [Pg.209]    [Pg.691]    [Pg.100]    [Pg.275]    [Pg.185]    [Pg.157]    [Pg.183]    [Pg.24]   
See also in sourсe #XX -- [ Pg.21 , Pg.29 , Pg.100 , Pg.275 ]

See also in sourсe #XX -- [ Pg.275 ]

See also in sourсe #XX -- [ Pg.24 ]



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Tolypothrix

Tolypothrix nodosa [Tolyporphin

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