Multidrug resistance proteins/genes

Lorico A, Rappa G, Finch RA, Yang D, Flavell RA, Sartorelli AC. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res 1997 57(23) 5238-5242. 

Kool M, van der LM, de Haas M, Baas F, Borst P. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res 1999 59(1) 175 182. 

H.M. Kauffmann and D. Schrenk. Sequence analysis and functional characterization of the 5 -flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem Biophys Res Commun. 245 325-331 (1998). 

Letoumeau, I. J., Deeley, R. G., and Cole, S. P. (2005) Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRPl/ABCCl). Pharmacogenet. Genomics. 15,647-657. 

Lautier D, Canitrot Y, Deeley RG, Cole SPC. Multidrug resistance mediated by the multidrug resistance protein (MRP) gene. Biochem Pharmacol 1996 52 967-977. 

Cells have been stained successfully for nuclear proteins related to proliferation (for example, PCNA, Ki-67, and various cyclins, which will be discussed in the chapter on DNA) and to tumor suppression (for example, p53, c-myc, and the retinoblastoma gene product). They have also been stained for proteins bound to interior membrane surfaces (e.g., Bcl-2, multidrug resistance protein [MDR], and P-gly-coprotein), and many strictly cytosolic proteins have been analyzed (like tubulin, hemoglobin, surface proteins that exist intracellularly at various stages of differentiation, and many cytokines). 

Mor-Cohen R, Zivelin A, Rosenberg N, Shani M, Muallem S, Seligsohn U. Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. J Biol Chem 2001 276 36923-36930. 

Tsujii H, Konig J, Rost D, Stockel B, Leuschner U, Keppler D. Exon intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. Gastroenterology 1999 117 653-660. 

Leier I, Hummel-Eisenbeiss J, Cui Y, Keppler D (2000) ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int 57 1636-1642 Leier I, Jedlitschky G, Buchholz U et al. (1994a) The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 269 27807-27810... 

Zhou, D., Zittoun, R., and Marie, J. (1995) Expression of multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) genes in acute myeloid leukaemia. Leukaemia 9, 1661-1666. 

---