Curcumin multidrug resistance

Some metabolites of curcumin (particularly tetrahydrocurcumin) may also participate in producing the observed effects of curcumin in different models because these metabolites display greater stabilities than the parent curcumin molecule at physiological pH. Recent data show similar modes of action of curcumin metabolites regarding antioxidant enzyme induction and inhibition of multidrug-resistant proteins. " Additional data indicate that curcumin may even act against other types of diseases such as atherosclerosis " " and Alzheimer s disease. " - " ... [Pg.139]

Chearwae, W. et al.. Modulation of the function of the multidrug resistance-linked ATP-binding transporter ABCG2 by the cancer chemopreventive agent curcumin. Mol. Cancer Then, 5, 1995, 2006. [Pg.146]

Ganta, S. and Amiji, M. (2009) Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Molecular Pharmacology, 6 (3), 928-939. Sonneville-Aubrun, O., Simonnet, J.-T. and L Alloret, F. (2004) Nanoemulsions a new vehicle for skincare products. Advances in Colloid and Interface Science, 108-109, 145-149. [Pg.171]

The in vitro antitumor activity of curcumin in HPV-associated cells has been established [Roy et al., 2002]. Curcumin modulates the in vitro expression and function of Pgp in multidrug-resistant human KB-V1 cells [Anand et al., 2008 Chearwae et al., 2004] and sensitizes cisplatin-resistant SiHa cells to cisplatin-induced apoptosis [Venkatraman et al., 2005], indicating its ability to reverse MDR in cervical cancer cells. The effect of curcumin in HPV-associated cells was found to involve the down-regulation of viral oncogenes, NF-kB and AP-1 [Anand et al., 2008 Divya and Pillai, 2006],... [Pg.369]

Choi BH, Kim CG, Lim Y, Shin SY, Lee YH. 2008. Curcumin down-regulates the multidrug-resistance mdrlb gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett 259 111-118. [Pg.445]

Co-encapsulated doxorubicin and curcumin in chitosan/polyCbutyl cyanoacrylate) NPs Reversion of multidrug resistance [277]... [Pg.85]

Duan J, et al. Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm. [Pg.111]

Synthesis of curcumin mimics with multidrug resistance reversal activities... [Pg.92]

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