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Pumps multidrug resistance

Biochemical mechanisms of resistance 3.5 Multidrug resistance pumps... [Pg.181]

Wigler, P.W. and F.K. Patterson. 1994. Reversal agent inhibition of the multidrug resistance pump in human leukemic lymphoblasts. Biochim Biophys Acta 1189 (1) 1. [Pg.109]

Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I (1992) Partial purification and reconstitution of the human multidrug-resistance pump characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci USA 89 8472-8476... [Pg.247]

NATURAL PRODUCTS AS MULTIDRUG RESISTANCE PUMP (MDR) INHIBITORS... [Pg.437]

A new method of bioactivity-directed fractionation, based on multidrug resistant pump (MDR) inhibition in Staphylococcus aureus, was reported for medicinal plants. This work resulted in the isolation, from berberine-containing Berberis species, two compounds that are themselves devoid of antibacterial activity, but that form potent synergistic couples with a sub-inhibitory concentration of berberine. The bacterial MDR pump inhibitors were identified as the flavonolignan 2 and the porphyrin 3 [98]. The isoflavones not only enhanced the antibacterial activity of the natural product, berberine. Fig. 4, but also the activity of synthetic... [Pg.438]

Bioassay-guided fractionation of an extract of Artemisia annua was conducted in order to assess the possible presence in the plant material of inhibitors of bacterial multidrug resistance pumps [218]. Fractions were tested for Staphylococcus aureus growth inhibition in the presence of a subinhibitory dose of weak antibacterial alkaloid berberine. Active fractions yielded the flavones chrysoplenol D and chrysoplenetin,... [Pg.489]

Chung, Y.J. and Saier, M.H., Jr. (2001) SMR-type multidrug resistance pumps. Current Opinion in Drug Discovery eC Development, 4 (2), 237-245. [Pg.147]

RND)-type multidrug resistance pumps the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition. Molecular Microbiology, 46 (3), 889-901. [Pg.151]

Lewis, K. (1994). Multidrug resistance pumps in bacteria Variations on a theme. Trends Bio-chem. Sci. 19, 119-123. [Pg.498]

Poget SF, Cahill SM, Girvin ME (2007) Isotropic bicelles stabilize the functional form of a small multidrug-resistance pump for NMR structural studies. J Am Chem Soc 129 2432-2433... [Pg.174]

Guz NR, Stermitz FR, Johnson JB, et al. (2001) Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump structure - activity relationships. J Med Chem 44 261-268... [Pg.261]

Applications of Tc-sestamibi to study drug transporters and of related Plasmodium falciparum multidrug resistance pump (pfMDR) inhibitors for malaria... [Pg.22]

See other pages where Pumps multidrug resistance is mentioned: [Pg.196]    [Pg.196]    [Pg.145]    [Pg.147]    [Pg.157]    [Pg.107]    [Pg.153]    [Pg.210]    [Pg.139]    [Pg.140]    [Pg.197]    [Pg.391]    [Pg.68]    [Pg.444]    [Pg.4482]    [Pg.170]    [Pg.209]    [Pg.71]    [Pg.937]   
See also in sourсe #XX -- [ Pg.60 , Pg.63 , Pg.65 , Pg.71 ]



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