Applications of Hyaluronic Acid Nanoparticles in Reversing Tumour Multidrug Resistance

5 Applications of Hyaluronic Acid Nanoparticles in Reversing Tumour Multidrug Resistance 

Since our group was interested in reversing the resistance in lung tumours, we chose a pair of resistant/sensitive NSCLC and SCLC cell lines and identified the genes that were overexpressed in the resistant cells compared to their companion sensitive cell lines [23]. Using the appropriate set of primers and by running reverse transcription polymerase chain reaction, we identified two overexpressed pump mediated (mdr-1, mrp-1) and two overexpressed non-pump mediated 

2 Combination Smaii Interfering Ribonucleic Acid and Chemotherapy Drug Treatment using Hyaluronic Acid Particles 

3 Restoring Drug Sensitivity and Improving Efficacy in Resistant Modeis 

Based on the data that we gathered, we designed our combination efficacy study with two rounds of treatment of HA-ODA/cisplatin and HA-PEI/HA-PEG with survivin and/or bcl-2 siRNA to accommodate 

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