Mouse lymphocytic leukemia

Li T, Fan GX, Wang W, Yuan YK. 2007. Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo. Int Immtmopharmacol 7 1221-1231. 

Simon et al also reported antitumor activity with auranofin using mouse lymphocytic leukemia P388 (59). 

KB human epidermoid carcinoma P-388 mouse lymphocytic leukemia A-549 lung adenocarcinoma HT-29 colon adenocarcinoma HL-60 human leukemia... 

Lumonadio et al. isolated five quassinoids from the root bark of Hannoa klaineana. Of these quassinoids, only 15-desacetyl-undulactone (70) was active against P-388 mouse lymphocytic leukemia cells and colon 38 adenocarcinoma in mice. Undulactone (71) and especially 15-0-"-D-glucopyranosyl-21-hydroxy-glaucarubolone (72) were more toxic, while 6a-tigloyloxy-glaucarubol (73) and 21-hydroxy-glaucarubolone (74) were inactive [27]. 

At the request of Health and Welfare Canada, the U.S. National Cancer Institute conducted animal tests on a sample submitted by Resperin Corp. In a mouse lymphocytic leukemia system, essiac showed no activity, but it did show toxicity at the highest levels tested. ... 

L1210 Mouse lymphocytic leukemia cell line... 

Iridolactones — triohimas A (61), B (123) and C (124) — isolated from Chinese diuretic herb Triosteum himalayanum exhibited in vitro cytotoxicity against L1210 (mouse lymphocytic leukemia) ceU by inhibiting proliferation about 13%, 11 %, and 18%, respectively, in MTT assay at 50 pM concentration [10]. 

Seleno- and 6-thio-D-galactose esters of dimethylarsinous acid have been synthesized by reaction of the appropriate 6-selenol or 6-thiol with dimethylarsinous chloride (Schemes 8 and 9). Removal of the isopropylidene groups in the ester (17) by means of Dowex-1 (H+) in aqueous methanol also removed the dimethylarsenyl group and the parent galactose ester was not synthesized. Compound (18) was shown to be carcinostatic against mouse lymphocytic leukemia in in vivo tests. Mass spectral and u.v. data of the products were also reported. ... 

Kinases Abl kinase Mouse cDNA Cancer, acute lymphocytic leukemia, chronic myelocytic leukemia, chronic neutrophilic leukemia Regulation of cytoskeletal organization and movement... 

Although the allocolchicinoids allocolchicine (12) and /V-acetylcolchinyl methyl ether (58) were found to be highly potent in vitro, their in vivo activity in the P388 lymphocytic leukemia mouse screen, with TIC values of 114 for 12, and 108 for 58, at the highest doses, was much less than expected (115). It may well be that the isomerization of these compounds to inactive isomers which occurs much easier in the alio series is the reason for the relatively weak in vivo activity of the alio compounds so far tested. 

See also Chapter 7, Section 4.1. An investigation details the isolation of (Z)-l, 8-pentadecadiene from E. angustifolia and E. pallida. This root oil constituent has inhibitory effects against Walker carcinosarcoma 256 and P-388 lymphocytic leukemia in the mouse and rat, respectively (18). 

The extracts from a large collection of Dokhdla auricuhria sea hares from the Indian Ocean were evaluated at the National Cancer Institute and showed an anticancer effect in the P388 lymphocytic leukemia mouse model. After 15 years of intense effort, an exceptionally potent toxin known as dolastatin 10 was isolated and its structure determined using extensive degradation by hydrolysis in concert with 2D NMR and various MS methods. The peptide was... 

Extracts of Jatropha gossypiifolia L. and related species have been used for many years in Costa Rica to treat cancerous growths. An alcoholic extract of the roots of Jatropha gossypiifolia (supplied by J. A. Saenz Renauld of the University of Costa Rica) was found by CCNSC to show inhibitory activity against four standard animal tumor systems (sarcoma 180, Lewis lung carcinoma, and lymphocytic leukemia P-388 in the mouse, and the Walker 256 intramuscular carcinosarcoma in the rat) and in vitro... 

Cytotoxicity by palytoxins has also been demonstrated in human bronchial epithelial cells [69], 3T3 Swiss mouse cells [70], V79 Chinese hamster lung cells [71], H 2981 human lung adenocarcinoma cells [72], EL-4 murine T-lymphoma cells [72], HL-60 human promyelocytic leukemia cells [73], and by an extract of O. siamensis in neuroblastoma cells [19], Palytoxin was shown to be highly toxic to P-388 lymphocytic leukemia cells [15]. Ostreocin D was significantly less toxic than palytoxin to the last-named cells [15]. Palytoxin, at very low concentration, inhibited the motility... 

Tumor-inhibiting against mouse P388 lymphocytic leukemia and in Ehrlich ascites tumor-test... 

In the mouse the Moloney retrovirus is fully mature, enveloped, and induces lymphocytic leukemia. Deprived of its envelope, the Moloney retrovirus induces soft tissue sarcomas, the most dominant of these tumors being the rhabdomyosarcoma [1806a, b, 1807a, b]. In tissue cultures, murine leukemogenic viruses lose... 

A number of studies have analyzed the efficacy of berberine in vivo against transplanted hematologic tumor cell fines as well as during virus-induced leukemia. Specifically, it has been showed that berberine has antitumoral potential in vivo against transplanted mouse acute lymphocytic leukemia P388 [112] and acute myeloid leukemia WEHI-3 [151]. fii addition, this alkaloid was able to inhibit the progression of erythroleukemia induced by mouse rebovirus. Friend, in immunocompetent mice [152]. 

Fig.5). Thus far, the highly pepstatin-sensitive forms of cathepsin D have been found only in the lymphoid tissues of rodents rat spleen, thymus, lymph node cells, and lymphocytes, mouse spleen and thymus, a mouse-derived leukemia L1210 line, and hamster spleen.

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