Inhibition tumor

Rheb Elevated in many tumor cells, Rheb may be the critical target by which farnesyl transferase inhibitors inhibit tumor growth... 

Kang, S.Y. et al., Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce prohferation of human colon cancer cells. Cancer Lett., 194, 13, 2003. 

Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol 2004 172(5) 2853-2860. 

Jl. Jaattela, M., Overexpression of major heat shock protein HSP70 inhibits tumor necrosis factor-induced activation of phospholipase A2. J. Immunol. 151,4286-4294 (1993). 

K9. Kilboum, R. G., Gross, S. S., Jubran, A., Adams, J., Griffith, O. W., Levi, R., and Lodato, R. F., A,c -Methyl-L-arginine inhibits tumor necrosis factor-induced hypotension. Proc. Natl. Acad. Sci. USA. 87, 3629-3632 (1990). 

P16. van der Poll, T., Coyle, S. M., Barbosa, K., Braxton, C. C., and Lowry, S. F., Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin-10 production during human en-dotoxemia. J. Clin. Invest. 97,713-719 (1996). 

The follicles are used to treat asthma and cough and to mitigate painful swollen breasts. A paste of the leave is applied to contusion. Essential oil distilled from the follicles induced apoptotic death in HepG2 human hepatoma cells in a concentration- and time-related manner, and inhibited tumor development of mice inoculated with Huh-7 human hepatoma cells (33). 

Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ (2005) Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing s sarcoma. Cancer Res 65 8984—8992... 

The major types of drug therapy used in IBD include aminosalicylates, glucocorticoids, immunosuppressive agents (azathioprine, mercaptopu-rine, cyclosporine, and methotrexate), antimicrobials (metronidazole and ciprofloxacin), and agents to inhibit tumor necrosis factor-a (TNF-a) (anti-TNF-a antibodies). 

Arzoxifene, a third-generation SERM, has demonstrated in experimental, preclinical, and presurgical studies its ability to inhibit tumoral proliferation and prevent bone loss. A randomized trial of arzoxifene vs. placebo has been initiated in late postmenopausal women to evaluate its preventive effect on breast cancer and vertebral fractures. 

Substituted analogues of /i-carbolin-l-onc 47 have also been found to inhibit tumor cell proliferation. For example, Hu and coworkers have reported that /l-carbolin-l-one 51 inhibited cell proliferation of HeLa cells with an... 

Further modifications of the CAAX tetrapeptide structure led to inhibitor 3 which blocked H-Ras farnesylation with an IC50 of 11 nmol/1 [23]. Tumor cell lines expressing mutant H- and N-Ras were most sensitive against this compound that inhibits tumor growth of EJ-1 human bladder carcinomas by about... 

Inhibits H K -ATPase Inhibits tumor cell division... 

Whitmore M, Li S, Huang L. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth. Gene Ther 1999 6 1867. 

The DKPs cyclo(His-Ala) and cyclo(His-Gly) proved to have promising anticancer activity comparable with that observed for cisplatin. Cyclo(His-Ala) in particular demonstrated an ability to inhibit tumor growth in HT-29, HeLa, and MCF-7 cancer cell lines. Cyclo(His-Gly) however, only had a marked effect on MCF-7 carcinoma cells at a concentration of 100 pmol 1. Both DKPs at a concentration of 0.5 mmolwere effective against two of the three Gram-positive bacteria, that is, Bacillus and S. aureus. Cycfo(His-Gfy) was more effective against Klebsiella pneumoniae than cyclo(His-Ala). Cyclo(His-Afa) and cycfo(His-Gfy) inhibited the growth of C. albicans by 66.3 and 47%, respectively. 

Torisel ) antibiotic NP arrest in ttie G1 phase, and inhibits tumor angiogenesis by reducing synthesis of vascular endothelial growth factor (VEGF) ... 

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