Cytoskeletal organization

Maciver, S.K, (1987). Cytoskeletal Organization in Amoeboid Locomotion. Ph.D thesis. University College, London. 

In human vaginal-cervical cells, the estrogen-induced increase in permeability is mediated in part by decreases in R, s that involve fragmentation of the cytoskeleton [23], The effects of estrogen on cytoskeletal organization involve modulation of both cortical actin [29] and myosin [45] (Figure 15.4A, C, D). 

Kinases Abl kinase Mouse cDNA Cancer, acute lymphocytic leukemia, chronic myelocytic leukemia, chronic neutrophilic leukemia Regulation of cytoskeletal organization and movement... 

Kapp, K., Knobloch, J., SchulSler, P., Sroka, S., Lammers, R., Kunz, W. and Grevelding, C.G. (2004) The Schistosoma mansoni Src kinase TK3 is expressed in the gonads and likely involved in cytoskeletal organization. Molecular and Biochemical Parasitology 138, 171-182. 

In addition to Ras, a number of other proteins are known to be substrates for FTase (many of unknown identity or function, determined by 2-D gel shift experiments in the presence and absence of FTI) these may also play a part in determining relative susceptibility to FTase inhibition.46 In particular, RhoB, a farnesylated protein involved with the formation of actin stress fibers and cytoskeletal organization, has been implicated in the growth-inhibitory consequences of FTase inhibition.47,48 Another study using the FTI 19 found that growth inhibition in soft agar of a panel of human tumor cell lines correlated with the mutational status of the H-and N-Ras proteins, but not with K-Ras mutations.49 In this study also, cells with genetic defects in addition to ras were sensitive to FTase inhibition. 

Kubota K, Kumamoto N, Matsuzaki S, Hashimoto R, Hattori T, et al. 2009. Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization. Biochem Bio-... 

Takenawa, T., and Itoh, T., 2001, Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim. Biophys. Acta 1533 190-206. 

Akiyama, S. K., Yamada, S. S., Chen, W. T. and Yamada, K. M. (1989). Analysis of fibronectin receptor function with monoclonal antibodies roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J. Cell Biol. 109, 863-875. 

Joltnson, W. T., and Dufault, S- N. (1989). Altered cytoskeletal organization and secretory response of thrombin-activated platelets from copper-deficient rats. /. N iir. 119,1404-1410. 

Toxin-mediated glucosylation of Rho explains the cytoskeletal disruption seen in cells treated with either of the C. difficile toxins. Somewhat differing effects of both toxins have been reported on the cytoskeletal organization in Hep-2 cells (Fiorentini eta/., 1989). 

Ser/Thr O-linked Gn is found primarily in the cytoplasm and in the nucleus. The role of O-Gn as regulating modification is not completely understood. O-Gncylation appears to be as abundant as phosphorylation, and is a highly dynamic and a regulated process [141]. O-Gn may have a role in modulating either the phosphorylation state or the assembly and disassembly of multimeric protein complexes in several major cellular systems including transcription, nuclear transport, and cytoskeletal organization [142]. 

Kumar, S., Maxwell, I.Z., Heisterkamp, A., Polte, T.R., Lele, T.P., Salanga, M., Mazur, E. and Ingber, D.E. (2006) Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys. J., 90, 3762-3773. 

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