Human promyelocytic leukemia cells

Martelli AM, Bortul R, Bareggi R, et al. The pro-apoptotic drug camptothecin stimulates phospholipase D activity and diacylglycerol production in the nucleus of HL-60 human promyelocytic leukemia cells. Cancer Res 1999 59 3961-3967. 

Nakatani N, Ichimaru M, Moriyasu M, Kato A. Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin. Biol Pharm Bull 2005 28 83-86. 

Nara, E., H. Hayashi, M. Kotake, K. Miyashita, and A. Nagao. 2001. Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells. Nutr Cancer 39(2) 273-283. 

HETE, 12-hydroxyeicosatetraenoic acid HL60, human promyelocytic leukemia cells... 

Classic antioxidants, vitamin E, vitamin C, and others can suppress the activation of apoptosis. For example, ascorbic acid prevented cytochrome c release and caspase activation in human leukemia cells exposed to hydrogen peroxide [128], Pretreatment with A -acctylcystcinc, ascorbate, and vitamin E decreased homocysteine thiolactone-induced apoptosis in human promyelocytic leukemia HL-60 cells [129]. Resveratrol protected rat brain mitochondria from anoxia-reoxygenation damage by the inhibition of cytochrome c release and the reduction of superoxide production [130]. However, it should be mentioned that the proapoptotic effect of ascorbate, gallic acid, or epigallocatechin gallate has been shown in the same human promyelocytic leukemia cells [131]. 

Nauseef, W. M. (1986). Myeloperoxidase biosynthesis by a human promyelocytic leukemia cell line Insight into myeloperoxidase deficiency. Blood 67,865-72. 

Seo HJ, Surh YJ. (2001) Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. Mutat Res 496 191-198. 

Hayakawa Y, Nakagawa M, Kawai H, Tanabe K, Nakayama H, Shimazu A, Seto H, Otake N. (1983) Studies on the differentiation inducers of myeloid leukemic cells 111. Spicamycin, a new inducer of differentiation of HL-60 human promyelocytic leukemia cells. J Antibiot 36 934-937. 

Grant S, Turner A, Bartimole TM, Nelms P, Joe VC, Jarvis WD (1994) Modulation of l-p-D-arabinofiiranosylcytosine-induced apoptosis in human promyelocytic leukemia cells by staurosporine and other inhibitors of protein kinase C. Oncol Res 6 87-99... 

Tochisawa, K. (1997). Effect of docosahexaenoic acid containing phospholipids on HL-60 human promyelocytic leukemia cell differentiation and their mechanism involved. "A master s thesis submitted to the graduate school of fisheries sciences, Hokkaido University", pp. 1-136. 

Tochisawa, K., Hosokawa, M., Kohno, H., Odashima, S., and Takahashi, K. (1997). Effect of phospholipids containing docosahexaenoic acid on differentiation and growth of HL-60 human promyelocytic leukemia cells. J. Jpn. Oil Chem. Soc. 46, 383-390. 

Jarvis, W.D., Turner, A.J., Povirk, L.F., Traylor, R.S., and Grant, S., Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C, Cancer Res., 54, 1707, 1994. 

Chang, Y.C., Huang, H.P, Hsu J.D., Yang, S.F., and Wang, C.J., Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells, Toxicol. Appl. Pharmacol., 205, 201-212, 2005. 

Daphneticin (12), isolated from Daphne tangutica, showed cytotoxic activity against Walker carcinosarcoma ascites cells (68) but was inactive against KB cells (68). In vitro studies showed cleomiscosin A (9), isolated from the chloroform extract of Brucea javanica, to be active against the murine P-388 lymphocytic leukemia cell line (EDsq = 0.4 pg ml ), but inactive against the KB test system (57). Luyengi et al. reported the lack of activity of the same compound when evaluated against HL-60 human promyelocytic leukemia cells (59). 

Optical trapping by two counter propagating diode laser beams 1,070 nm, Raman 785 nm through microscope objective HK60 human promyelocytic leukemia cells Cytoplasm 643, 852, 939, 1,660 cm nucleus. A, T, G, and C at 785, 830,895,1,048,1,093 cm and thymine at 751 cm Nucleus, cytoplasm, and membrane are distinguished in one cell... 

The second cannabinoid receptor sub-type, CB2, was derived from a human promyelocytic leukemia cell HL60 cDNA library (Munro et al. 1993). The human CB2 receptor exhibits 68% identity to the human CBi receptor within the transmembrane regions, 44% identity throughout the whole protein. The CB2 receptor in both rat (Griffin et al. 2000) and mouse (Shire et al. 1996) has been cloned as well. A helix net representation of the human CB2 receptor sequence is presented in Fig. 2. Unlike the CB 1 receptor, which is highly conserved across human, rat, and... 

Tanaka, H. et al. (1983) la,25-dihydroxyvitamin D3 induces differentiation of human promyelocytic leukemia cells (HL-60) into monocyte-macrophages, but not into granulocytes. Biochemical and Biophysical Research Communications, 117,... 

Mangelsdorf, D.J. et al. (1984) 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60) receptor-mediated maturation to macrophage-like cells. The Journal of Cell Biology, 98, 391-398. 

Arsenic trioxide is an antineoplastic agent that causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR alpha. It is indicated in the treatment of refractory or relapsed acute promyelocytic leukemia (APT). 

Studies of the methanolic extract of Alpinia oxyphylla have shown that this extract suppresses the promotion of skin tumors in mice and that it induces apoptosis in cultured human promyelocytic leukemia cells. In addition, two phenolic diarylheptano ids isolated from the active extract, yakuchinone A and yakuchinone B, were found to ameliorate tumor promotion as well as inhibit both TPA-induced epidermal ornithine decarboxylase (ODC) activity and ODC RNA expression. Moreover, yakuchinones A and B reduced production of the TNF-a in the TPA-stimulated skin of mice. Furthermore, both compounds inhibited the TPA-induced expression of COX-2 at both transcriptional and... 

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