Lung adenocarcinoma

Yeh, S.L. and Hu, M.L., Oxidized [beta]-carotene inhibits gap junction intercellular communication in the human lung adenocarcinoma cell line A549, Food Chem. Toxicol., 41, 1677, 2003. 

Ogretmen, B., J. M. Kraveka, D. Schady, J. Usta, Y. A. Hannun, and L. M. Obeid. 2001. Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem 276(35) 32506-14. 

Miquel, K., Pradines, A., Terce, F., Sehni, S., and Favre, G., 1998, Compehhve inhibition of choline phosphotransferase by geranylgeraniol and famesol inhibits phosphatidylchohne synthesis and induces apoptosis in human lung adenocarcinoma A549 ceUs. JBiol Chem. 273 26179-26186... 

Wang H, Tan W, Hao B, Miao X, Zhou G, He F, Lin D (2003a) Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. Cancer Res 63 8057-8061... 

Pao, W., Miller, V. A., PoUti, K. A., et al. (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2, e73. 

Antimitotic agents Vinca alkaloids Lung adenocarcinoma... 

A549 cells (Human lung adenocarcinoma epithelial cell line). Subculture once a week, maintain in 5% CO, at 37°C. 

Meylan E, Dooley AL, Feldser DM et al (2009) Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 462 104-107... 

Xue W, Meylan E, Oliver TG et al (2011) Response and resistance to NF-kappaB inhibitors in mouse models of lung adenocarcinoma. Cancer Discov 1 236-247... 

Degrassi A, Russo M, Nanni C et al (2010) Efficacy of PHA-848125, a cyclin-dependent kinase inhibitor, on the K-Ras(G12D)LA2 lung adenocarcinoma transgenic mouse model evaluation by multimodality imaging. Mol Cancer Ther 9 673-681... 

Yoshida A, Tsuta K, Nitta H et al (2011) Bright-field dual color chromogenic in situ hybridization for the diagnosis of EML4-ALK-postitive lung adenocarcinomas. J Thorac Oncol 6 1677-1686... 

Achiwa H, Yatabe Y, Hida T, et al. Prognostic significance of elevated cyclooxygenase-2 expression in primary, resected lung adenocarcinoma. Clin Cancer Res 1999 5 1001-1005. 

Cytotoxic effect. Gas phase of mainstream cigarette smoke, in monolayer culture of mouse lung epithelial cells, produced an increase in cytotoxicity in a dose-dependent manner. Cell viability of cultures exposed to gas phase with only the nonorganic components was equivalent to controls. Removal of volatile organic constituents resulted in almost elimination of cytotoxicity of the smoke . Smoke condensate and tobacco extract, at high concentrations in Lewis lung adenocarcinoma cells and mice spleen lymphocytes, were cytotoxic. Smaller doses increased thymidine incorporation in both cell types. Lymphocytes were more susceptible to the toxic effect of tobacco prod-... 

Feldman. Cytotoxic and proliferative effect of tobacco products on Lewis lung adenocarcinoma cells and spleen lymphocytes. Allergol Immunopathol (Madr) 1989 17(5) 257-261. 

Chen G, Gharib TG, Huang CC, et al. (2002) Discordant protein and mRNA expression in lung adenocarcinomas. Mol Cell Proteomics 1, 304-13. 

Gharib TG, Chen G, Wang H, et al. (2002) Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma. Neoplasia 4, 440-5. 

B16 melanoma, Walker sarcoma, and M5076 forming liver metastasis have been used in the preclinical evaluation of HPMA copolymer-adriamydn conjugates [36]. Other tumors useful for secondary screening are MS-2 sarcoma, NMU-1 murine lung adenocarcinoma, and murine adenocarcinoma Colon 26. These have been used by Zunino et al. [147] to determine the activity of poly (carboxylic acid) immobilized anthracyclines. Mice inoculated intramuscularly with Lewis lung carcinoma have been used by Pratesi et al. [215] to assess the effect of a poly-L-aspartic acid/doxorubicin conjugate. 

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