Lymphoma B cell

AIDS (acquired immunodeficiency syndrome) is the final stage of disease caused by infection with HIV. In this stage, the vims infection has severely affected the immune system, causing a depletion of CD4+ T-helper cells. AIDS is characterized by the manifestation of typical diseases caused by opportunistic infections (Pneumocystis carinii pneumonia, CMV retinitis, candidiasis of the esophagus, cerebral toxoplasmosis), neurological manifestations, cachexia, or certain tumors (Kaposi sarcoma of the skin, B-cell lymphoma). [Pg.51]

Bcl-2 (B-cell lymphoma-related gene) is major mammalian gene that is known to inhibit apoptosis. [Pg.250]

BCL-2 Codes for a protein that blocks apoptosis Indolent B-cell lymphomas... [Pg.1279]

Rituximab is a monoclonal antibody to the CD20 receptor expressed on the surface of B lymphocytes the presence of the antibody is determined during flow cytometry of the tumor cells. Cell death results from antibody-dependent cellular cytotoxicity. The pharmacokinetics of rituximab are best described by a two-compartment model, with a terminal half-life of 76 hours after the first infusion and a terminal half-life of 205 hours after the fourth dose.36 Rituximab has shown clinical activity in the treatment of B-cell lymphomas that are CD20+. Side effects include hypersensitivity reactions, hypotension, fevers, chills, rash, headache, and mild nausea and vomiting. [Pg.1294]

Splenic marginal zone B-cell lymphoma ( villous lymphocytes)... [Pg.1374]

Lymphomas not included in Working Formulation mycosis fungoides, mantle cell lymphoma, monocytoid B-cell lymphoma, mucosa-associated lymphoid tissue (MALT), anaplastic large cell lymphoma, angiocentric lymphoma, angioimmunoblastic lymphadenopathy (AILD), Castleman s disease, adult T-cell leukemia/lymphoma. [Pg.1376]

Coiffer B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large B-cell lymphoma. New Engl J Med 2002, 346 235-242. [Pg.1383]

BR is a 62-year-old woman who was recently diagnosed with stage IV large B-cell lymphoma. Her bone marrow is positive for lymphoma, and she has type II diabetes and hypertension. [Pg.1468]

Jones D, Benjamin RJ, Shahsafaei A, Dorfman DM. The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood 2000 95 627-632. [Pg.346]

Alizedah AA et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000 403 503-511. [Pg.114]

Preliminary Phase I data for PCI-32765 in refractory B-cell lymphoma indicates a partial response in 5/16 patients [40]. The irreversibility of the binding interaction enables a direct assessment of target occupancy with a fluorescent probe [42]. In the Phase I study, target occupancy was essentially complete and downstream biomarkers (CD63, pERK) were significantly inhibited at 2.5 mg/kg/ day. [Pg.180]

As described in several monographs [4], bryostatin 1 exhibits significant in vitro and in vivo antineoplastic activity against a range of tumor cell lines including murine leukemia, B-cell lymphoma, reticulum cell sarcoma, ovarian carcinoma, and melanoma. It is also effective in the modulation of apoptotic function [5], the reversal of multidrug resistance [6], and stimulation of the immune system [7]. These unique features displayed by bryostatin 1 are attributed to its high affinity for protein kinase C (PKC) isozymes and its ability to selectively modulate their functions [8]. PKCs are a type of intracellular serine and threonine kinase that... [Pg.104]

Michel, R.B., Ochakovskaya, R., and Mattes, M.J. (2002) Antibody localization to B-cell lymphoma xenografts in immunodeficient mice importance of using residualizing radiolabels. Clin. Cancer Res. 8, 2632-2639. [Pg.1094]

B cell lymphoma (scFv) N -terminal rice a-amylase LP (leaves) FW... [Pg.93]

Tumor surface Ig 38C13 scFv B-cell lymphoma treatment N. benthamiana TMV coat protein Rice a-amylase SP + 60 pg/mL of intercellular medium 56... [Pg.237]

Diffuse large B-cell lymphomas are the most common lymphoma in patients of all ages but most commonly seen in the seventh decade. Extranodal disease is present at diagnosis in 30% to 40% of patients. The International Prognostic Index score correlates with prognosis. Diffuse aggressive lymphomas are sensitive to chemotherapy with cure achieved in some patients. [Pg.723]

Early-Stage Diffuse Large B-Cell Lymphoma... [Pg.723]

Alizadeh, A.A., et al., "Distinct Types of Diffuse Large B-Cell Lymphoma Identified by Gene Expression Profiling," Nature, 403, 503-511 (2000). [Pg.160]

Immunodeficiency has been associated with an increased incidence of viral-induced cancers, which tend to be more immunogenic than those that are chemically-induced. Cancers related to immunosuppression include leukemia and cancers of the skin (seen in transplant patients4) as well as Kaposi s sarcoma and EB V-associated B cell lymphomas (observed in HIV/AIDS patients). [Pg.37]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...