Leukemia, P388 mouse lymphocytic

Simon et al also reported antitumor activity with auranofin using mouse lymphocytic leukemia P388 (59). 

A number of studies have analyzed the efficacy of berberine in vivo against transplanted hematologic tumor cell fines as well as during virus-induced leukemia. Specifically, it has been showed that berberine has antitumoral potential in vivo against transplanted mouse acute lymphocytic leukemia P388 [112] and acute myeloid leukemia WEHI-3 [151]. fii addition, this alkaloid was able to inhibit the progression of erythroleukemia induced by mouse rebovirus. Friend, in immunocompetent mice [152]. 

The products were tested by the mouse P388 lymphocytic leukemia survival test and by the Ehrlich ascites tumor regression test. The polyphosphazene-plat-inum product showed an inhibition of 86% in the ascites test and a 5/7 survival after the eighth day for the P388 mouse test. 

Although the allocolchicinoids allocolchicine (12) and /V-acetylcolchinyl methyl ether (58) were found to be highly potent in vitro, their in vivo activity in the P388 lymphocytic leukemia mouse screen, with TIC values of 114 for 12, and 108 for 58, at the highest doses, was much less than expected (115). It may well be that the isomerization of these compounds to inactive isomers which occurs much easier in the alio series is the reason for the relatively weak in vivo activity of the alio compounds so far tested. 

The extracts from a large collection of Dokhdla auricuhria sea hares from the Indian Ocean were evaluated at the National Cancer Institute and showed an anticancer effect in the P388 lymphocytic leukemia mouse model. After 15 years of intense effort, an exceptionally potent toxin known as dolastatin 10 was isolated and its structure determined using extensive degradation by hydrolysis in concert with 2D NMR and various MS methods. The peptide was... 

Tumor-inhibiting against mouse P388 lymphocytic leukemia and in Ehrlich ascites tumor-test... 

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