ICAM-1 intercellular adhesion

Selected adhesion molecules represent yet another antibody target. Adhesion molecules, such as LFA-1 (leukocyte function-associated antigen-1) and ICAM-1 (intercellular adhesion molecule 1), play central roles in promoting migration of inflammatory cells to the sites of damage. Such activities underlie many of the symptoms of conditions such as rheumatoid arthritis. Inhibition of adhesion molecule function by administration of antibodies raised against them may, therefore, demonstrate therapeutic potential in some instances. [Pg.434]

ICAM-1 (intercellular adhesion molecule) this binds to CDlla-b/CD18... [Pg.552]

CBF, Cerebral blood flow CCAo, common carotid artery occlusion cGMP, cyclic guanine monophosphate ICAM-1, intercellular adhesion molecule-1 ICAo, internal carotid artery occlusion MCAo, middle cerebral artery occlusion NAA, A-acetyl-aspartate NOS, nitric oxide synthase SD, Sprague-Dawley SH, spontaneously hypertensive SOD, superoxide dismutase TUNEL, transferase dUTP nick-end labeling. [Pg.48]

OTG (n-Octyl-P-D-thioglucoside) HPMC (hydroxipropylmethylcelulose) PG (propylene glycol) PBS (phosphate buffer solution) ICAM-1 (intercellular adhesion molecule-1). ... [Pg.2745]

HRT Hormone-replacement therapy ICAM-1 Intercellular adhesion molecule IDE Intermediate-density lipoprotein IHD Ischemic heart disease IL Interleukin... [Pg.450]

FIGURE 15.4 Oxysterols may upregulate all steps in the transmigration of lenkocytes through the endothelial layer lining the arterial vessels. VCAM-1, vascular cell adhesion molecule-1 ICAM-1, intercellular adhesion molecule-1 MCP-1, monocyte chemotactic protein-1 MIP, monocyte inflammatory protein. [Pg.316]

Key PMN, polymorphonuclear leukocytes EC, endothelial cell lymphs, lymphocytes CD, cluster of differentiation iCAM, intercellular adhesion molecule LFA-1, lymphocyte function-associated antigen-1 PECAM-1, platelet endothelial cell adhesion cell molecule-1. [Pg.529]

ICAM intercellular adhesion molecule t-MIAA tele methyl imidazole acetic acid... [Pg.965]

Abs, Antibodies CD, celiac disease EM, endomysial antibodies GFD, gluten-free diet HLA-DQ2, human leukocyte antigen ICAM, intercellular adhesion molecule IFN, interferon IL, interleukin Lab laboratory tTG, tissue transglutaminase antibodies. [Pg.249]

GMP, granular membrane protein ODFR, oxygen-derived free radicals ELAM, endothelial leukocyte adhesion molecule IL-1, interleukin-1 TNF-alpha, tumor necrosis factor-alpha ICAM, intercellular adhesion molecule IFN-gamma, interferon -gamma VCAM, vascular cell adhesion molecule LFA, lymphocyte-associated antigen CR, complement receptor. [Pg.193]

HIV human immune deficiency virus HPV human papillomavirus HSV herpes simplex virus ICAM intercellular adhesion molecule IL interleukin IL-la interleukin 1 a LNA locked nucleic acid mRNA messenger RNA NK natural killer PKC protein kinase C ply rC poly ribocytosine PNA peptide nucleic acid poly rl poly ribinosine PTHrP parathyroid hormone-related peptide thermal melting temperature change in relative to DNA TAR transactivator response element VSV vesicular stomatitis virus... [Pg.156]

CD49 Cluster of differentiation 49 CD51 Known to be vitronectin receptor alpha chain CD54 Known to be Intercellular adhesion molecule-1 also known as ICAM-1... [Pg.280]

K. Drickamer, and A.-C. Roche, Oligolysine-based oligosaccharide clusters selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin, /. Biol. Chem., 278 (2003) 23922-23929. [Pg.385]

Alveolar epithelial cells (AECs) are connected with each other by various epithelial cell-cell contacts (i.e., tight junctions, adherens junctions and others). These contacts comprise several groups of proteins, such as occludin, zonula occludens (ZO-1, -2, -3), claudins, tricellulin, E-cadherin and intercellular adhesion molecule-1 (ICAM-1) [13-15], Their regulation and interplay, which has influence on epithelial barrier properties, however, is largely unknown to date. [Pg.261]

Note IL-1 = interleukin-1 GM-CSF = granulocyte-marcophage colony-simulating factor PDGF = platelet-derived growth factor TGF-)5 = transforming growth factor-) ICAM = intercellular leukocytic adhesion molecule ELAM = extracellular leukocytic adhesion molecule. [Pg.318]

Rat kidneys were perfused ex situ with phosphorothioate intercellular adhesion molecule (ICAM)-l AS-ODN and exposed to 30 min cold or warm ischaemia. After this time the kidneys were transplanted to syngeneic nephrectomized rats. Treatment with 10 mg antisense reduced the harmful effect of transplantation on renal function [132]... [Pg.148]

Haraldsen, G., Kvale, D., Lien, B., Farstad, I. N., and Brandtzaeg, P. (1996). Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J. Immunol. 56, 2558-2565. [Pg.192]