Tumor necrosis factor-alpha

Lignans show strong antitumor, antiviral and antibacterial activity, as well as influence upon expression of the tumor necrosis factor-alpha. [Pg.372]

Cytokines and biological response modifiers represent a broad class of therapeutic agents that modify the hosts response to cancer or cancer therapies. The enormous body information about their clinical uses and their side effects is beyond the scope of this essay that can only give illustrative examples. For an up-to-date information the reader can resort to reference [5]. As many as 33 different interleukins are known and the list continues to grow IL-2 used in the treatment of kidney cancer is one example. Interferon alpha is used for chronic myelogenous leukeia, hairy cell leukaemia and Kaposi s sarcoma. Interferons are also used in the treatment of chronic infections such as viral hepatitis. Tumor necrosis factor (alpha), G/GM/M-CSF, and several other cellular factors are used in treatment of various cancers. Many of these cytokines produce serious side effects that limit their use. [Pg.268]

Tumor necrosis factor alpha (TNFa) is a negative regulator of FATP expression and downregulates FATP mRNA and protein levels in several tissues. [Pg.498]

MA M12 M12.217 ADAM17 peptidase Potential drug target for control of formation of tumor necrosis factor alpha... [Pg.879]

Example on Tumor Necrosis Factor Alpha. The term tumor necrosis factor alpha can be readily identified from text. The GetLinks method fetches the local terms associated with the normalized term for the various sources from the Metastore. The local terms are then used for pointing to the original records and linking to specific applications (Table 31.5). [Pg.740]

Term to UltraLink tumor necrosis factor alpha Concept Type TARGET Normalized term TNF alpha Synonyms ... [Pg.741]

TUMOR NECROSIS FACTOR ALPHA STIMULATES THE GROWTH OF THE CLONOGENIC CELLS OF ACUTE MYELOBLASTIC LEUKEMIA IN SYNERGY WITH GRANULOCYTE / MACROPHAGE COLONY -STIMULATING FACTOR... [Pg.743]

Biber K, Zuurman MW, Dijkstra IM, Boddeke HW (2002) Chemokines in the brain neuroimmunology and beyond. Curr Opin Pharmacol 2 63-68 Blasko 1, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B (2000) Costimulatory effects of interferon-gamma and interleukin-1 beta or tumor necrosis factor alpha on the synthesis of Abetal-40 and Abetal-42 by human astrocytes. Neurobiol Dis 7 682-689... [Pg.291]

Liu IS, lohn GR, Sikora A, Lee SC, Brosnan CF (2000) Modulation of interleukin-1 beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. 1 Neurosci 20 5292-5299... [Pg.295]

Rossi D, BrambiUa L, Valori CF, Crugnola A, Giaccone G, Capobianco R, Mangier M, Kingston AE, Bloc A, Bezzi P, Volterra A (2005) Defective tumor necrosis factor-alpha-dependent control of astrocyte glutamate release in a transgenic mouse model of Alzheimer disease. J Biol Chem 280 42088-42096... [Pg.298]

Ahn SY, Cho CH, Park KG, Lee HI, Lee S, Park SK, Lee IK, Koh GY (2004) Tumor necrosis factor-alpha induces fractaUdne expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractaUdne expression. Am J Pathol 164 1663-1672 Alfano M, Schmidtmayerova H, Amelia CA, Pushkarsky T, Bukrinsky M (1999) The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains, [see comments]. J Exp Med 190 597-605 Ambrosini E, Alois F (2004) Chemokines and glial cells a complex network in the central nervous system. [Review] [239 refs]. Neurochem Res 29 1017-1038 Azuma Y, Ohura K (2002) Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NE-kappaB DNA binding in THP-1 differentiated to macrophagelike cells. Scand J Immunol 56 260-269... [Pg.332]

Other pro-inflammatory factors produced and secreted by these cell populations snch as interlenkins (IL) -1, -6, -12, and tumor necrosis factor alpha (TNF-a) are instrnmental in the resolution of bacterial clearance (Daley et al. 2005 Ishikawa and Miyazak 2005 Kudo et al. 2005 Man et al. 2007 Wang et al. 2005 Warner and Srinivasan 2004). [Pg.339]

Koka P, He K, Zack JA, Kitchen S, Peacock W, Fried 1, Tran T, Yashar SS, MerrUl JE (1995) Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J Exp Med 182 941-951... [Pg.371]

Pulliam L, West D, Haigwood N, Swanson RA (1993) HIV-1 envelope gpl20 alters astrocytes in human brain cultures. AIDS Res Hum Retroviruses 9 439 44 Pulliam L, Zhou M, Stubblebine M, Bitler CM (1998) Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor. J Neurosci Res 54 530-538... [Pg.374]

Larrick, J.W. and Wright, S.C. (1990). Cytotoxic mechanism of tumor necrosis factor alpha. FASEB J. 4, 3215-3223. [Pg.213]

Rychly DJ, DiPiro JT. Infections associated with tumor necrosis factor-alpha antagonists. Pharmacotherapy 2005 25 1181-1192. [Pg.878]

FIGURE 96-4. Pathophysiology of the hypercalcemia of malignancy. PTHrP, parathyroid hormone-related protein TGF-P, transforming growth factor P TNF-a, tumor necrosis factor alpha Ca2+, calcium IL-1, interleukin 1 IL-2, interleukin 2. [Pg.1483]

Jawa RS, Quaid GA, Williams MA, et al. Tumor necrosis factor alpha regulates CXC chemokine receptor expression and function. Shock 1999 11 385-390. [Pg.83]

Ahn S Y, Cho CH, Park KG, et al. Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression. Am J Pathol 2004 164(5) 1663-1672. [Pg.226]

Szekanecz Z, Shah MR, Harlow LA, Pearce WH, Koch AE. Interleukin-8 and tumor necrosis factor-alpha are involved in human aortic endothelial cell migration. The possible role of these cytokines in human aortic aneurysmal blood vessel growth. Pathobiology 1994 62(3) 134-139. [Pg.230]

Garton KJ, Gough PJ, Blobel CP, et al. Tumor necrosis factor-alpha-converting enzyme (ADAM 17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem 2001 276 37993-38001. [Pg.366]

C25. Cross, A. S., Sadoff, J. C., Kelly, N., Bemton, E., and Gemski, P., Pretreatment with recombinant murine tumor necrosis factor-alpha/cachectin and murine interleukin 1 -alpha protects mice from lethal bacterial infection. J. Exp. Med. 169,2021-2027 (1989). [Pg.112]

E10. Engel, A Kern, W. V., Miirdter, G., and Kern, P Kinetics and correlation with body temperature of circulating interleukin-6, interleukin-8, tumor necrosis factor alpha and interleukin-1 beta in patients with fever and neutropenia. Infection 22, 160-164 (1994). [Pg.114]

P16. van der Poll, T., Coyle, S. M., Barbosa, K., Braxton, C. C., and Lowry, S. F., Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin-10 production during human en-dotoxemia. J. Clin. Invest. 97,713-719 (1996). [Pg.125]

Shalaby, M. R., Waage, A., Aarden, L. A., and Espevik, T., Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo. Clin. Immunol. Immunopathol. 53,448-498(1989). [Pg.127]

Artis, D., Humphreys, N.E., Bancroft, A.J., Rothwell, N.J., Potten, C.S. and Grencis, R.K. (1999a) Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. Journal of Experimental Medicine 190, 953-962. [Pg.396]

Bennett, B.L., Cruz, R., Lacson, R.G. and Manning, A.M. (1997) Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB. Journal of Biological Chemistry 272, 10212-10219. [Pg.397]

Furuta, G.T., Schmidt-Choudhury, A., Wang, M.Y., Wang, Z.S., Lu, L., Furlano, R.I. and Wershil, B.K (1997) Mast cell-dependent tumor necrosis factor alpha... [Pg.398]

Lugli, S.M., Feng, N., Heim, M.H., Adam, M., Schnyder, B., Etter, H., Yamage, M., Eugster, H.P., Lutz, R.A., Zurawski, G. and Moser, R. (1997) Tumor necrosis factor alpha enhances the expression of the interleukin (IL)M receptor alpha-chain on endothelial cells increasing IL-4 or IL-13-induced Stat6 activation. Journal of Biological Chemistry 272, 5487-5494. [Pg.401]

Wattiez R et al. Human bronchoalveolar lavage fluid protein two-dimensional database study of interstitial lung diseases. Electrophoresis 2000 21 2703-2712. Yanagida M et al. Matrix assisted laser desorption/ionization-time of flight-mass spectrometry analysis of proteins detected by anti-phosphotyrosine antibody on two-dimensional-gels of fibrolast cell lysates after tumor necrosis factor-alpha stimulation. Electrophoresis 2000 21 1890-1898. [Pg.120]

Moreb JS, Turner C, Sreerama L, ZuCALI JR, SlADEK NE, SCHWEDER M. Interleukin-1 and tumor necrosis factor alpha induce class 1 aldehyde dehydrogenase mRNA and protein in bone marrow cells. Leuk Lymphoma 1995 20 77-84. [Pg.438]

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