Papillomavirus, human

Each virus type has different sets of oncogenes, which determine its pathogenicity and the clinical behavior of the infection. The main oncogenes include [Pg.240]

E4 encodes the protein causing the collapse of cytoplasmic cytokeratin [Pg.241]

E5 responsible for EGF signal transmission and growth regulatory mechanisms [Pg.241]

E7 an oncogene reacting with the retinoblastoma (Rb) tumor suppressor gene. [Pg.241]

The above-described mechanisms make the detection of HPV an important parameter for the follow-up and further treatment of different dysplastic and neoplastic epithelial lesions. In situ hybridization and different PCR-based molecular methods are the most common used molecular tools to detect HPV in various specimens. [Pg.242]

NB Other relevant data taken into consideration in making the overall evaluation) Human papillomavirus type 31 (Vol. 64 1995)... [Pg.98]

Examples of the application of SAR-by-NMR include the design of stromelysin and human papillomavirus E2 protein inhibitors [7, 8]. [Pg.1109]

Hajduk PJ, Dinges J, Miknis GF et al (1997) NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein. J Med Chem 40 3144-3150... [Pg.1109]

Pan WH, Xin P, Morrey JD, Clawson GA (2004) A self-processing ribozyme cassette utility against human papillomavirus 11 E6/E7 mRNA and hepatitis B virus. Mol Ther 9 596-606... [Pg.294]

The most common risk factors for skin cancer development after transplantation include increased age, excessive ultraviolet (UV) light exposure, high degree of immunosuppression, Fitzpatrick skin types I, II and III, history of skin cancers, and infection by human papillomavirus.77... [Pg.850]

Genital warts, caused by the human papillomavirus (HPV), are regularly encountered in primary care. Responsible for various visible, keratotic, and non-keratotic manifestations, HPV has nearly 120 noted strains, some of which have been linked to squamous cell carcinoma.20... [Pg.1168]

In one study by Hood et al., 282 of 1153 identified proteins were identified by at least 2 unique tryptic peptides from FFPE prostate cancer (PCa) tissue.9 According to the gene ontology classification of the proteins identified, -65% of proteins were predicted to be intracellular proteins, while -50% of the total human proteome is predicted to be located in the intracellular compartment. Additionally, 20% of the proteins identified in the PCa tissue were classified as membrane proteins, which is significantly less than the predicted 40% for the human proteome. This relative disparity is not unexpected, considering the Liquid Tissue sample preparation kit lacks specific protocols for membrane protein extraction. The Liquid Tissue method has also been used for proteomics studies of a variety of FFPE tissue samples, including pancreatic tumors,28 squamous cell carcinoma,4 and oral human papillomavirus lesions.27... [Pg.341]

A CL ISH assay for the detection of human papillomavirus (HPV) DNA was developed, in which the hybridization reaction was performed using either digoxigenin-, biotin-, or fluorescein-labeled probes [64], The hybrids were visualized using AP as the enzyme label and a highly sensitive 1,2-dioxetane phosphate as chemiluminescent substrate. This assay was applied to biopsy specimens from different pathologies associated with HPV, which had previously proved positive for HPV DNA by polymerase chain reaction (PCR). The analytical sensitivity was assessed using samples of HeLa and CaSki cell lines, whose content in HPV DNA is known (10-50 copies of HPV 18 DNA in HeLa cells and 400-600 copies... [Pg.490]

Alvarez-Salas, L.M., Benitez-Hess, M.L., and DiPaolo, J.A. 2003. Advances in the development of ribozymes and antisense oligodeoxynucleotides as antiviral agents for human papillomaviruses. Antiviral Therapy 8(4), 265-278. [Pg.462]

C trachomatis, Cardnerella vaginalis, herpes simplex virus, human papillomavirus, N. [Pg.508]

Human papillomavirus infection External genital warts... [Pg.520]

Imiquimod 5% cream applied at bedtime three times weekly for up to 16 weeks" Cryotherapy with liquid nitrogen, or trichloroacetic acid or bichloracetic acid 80-90% as for external human papillomavirus warts repeat weekly as necessaiy Surgical removal (not for vaginal or urethral meatus warts)... [Pg.520]

The quadrivalent human papillomavirus vaccine is recommended as a three-dose series (0, 2, and 6 months) for all females 11 to 12 years old. The vaccine is licensed for females 9 to 26 years of age. [Pg.583]

C4. Coutlee, F., Provencher, D., and Voyer, H., Detection of human papillomavirus DNA in cervical lavage specimens by a nonisotopic consensus PCR assay. J. Clin. Microbiol. 33, 1973-1978 (1995). [Pg.35]

Ll. Lorinez, A. T., Reid, R., Jenson, A. B., Green, M. D., Lancaster, W., and Kurman, R. J., Human papillomavirus infection of the cervix Relative risk associations of 15 common anogenital types. Obstet. Gynecol. 79, 328-337 (1992). [Pg.71]

Agarwal C, Rorke EA, Irwin JC, and Eckert RL [1991] Immortalization by human papillomavirus type 16 alters retinoid regulation of human ectocervical epithelial cell differentiation. Cancer Res 51 3982-3989... [Pg.361]

Choo CK, Rorke EA, and Eckert RL [1993] Calcium regulates the differentiation of human papillomavirus type 16 (HPV16) immortalized ectocervical epithelial cells, but not the expression of the papillomavirus E6 and E7 oncogenes. Exp Cell Res 208 161-169... [Pg.361]

Sizemore N and Rorke EA [1993] Human papillomavirus 16 immortalization of normal human ectocervical epithelial cells alters retinoic acid regulation of cell growth and epidermal growth factor receptor expression. Cancer Res 53 4511-4517... [Pg.361]

Rorke EA and Jacobberger JW [1995] Transforming growth factor-beta 1 (TGF beta 1) enhances apoptosis in human papillomavirus type 16-immortalized human ectocervical epithelial cells. Exp Cell Res 216 65-72... [Pg.361]

DiPaolo, J. A., N. C. Popescu, L. Alvarez, and C. D. Woodworth. 1993. Cellular and molecular alterations in human epithelial cells transformed by recombinant human papillomavirus DNA. Crit Rev Oncog 4(4) 337-60. [Pg.630]

James, M. A., J. H. Lee, and A. J. Khngelhutz. 2006. Human papillomavirus type 16 E6 activates NF-kappaB, induces cIAP-2 expression, and protects against apoptosis in a PDZ binding motif-dependent manner. J Virol 80( 11 ) 5301—7. [Pg.633]

Coursen, J. D., W. P. Bennett, L. Gollahon, J. W. Shay, and C. C. Harris. 1997. Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human papillomavirus-16 E6 and E7 genes. Exp Cell Res 235( 1 ) 245-53. [Pg.636]

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