Monocyte chemotactic protein 1 MCP

Finally, a new area of research has concentrated on monocyte chemotactic protein-1 (MCP-1), a 76-amino acid peptide that is one of the best-studied members of the C-C chemokine subfamily. Recent human and animal studies indicate that the recruitment of macrophages to the arterial lesion is predom-... 

Inhibition of leucocyte adhesion to endothelium. By acting on the gene transcription factor called nuclear factor kappa B (NFkB), NO limits the expression by endothelial cells of monocyte chemotactic protein-1 (MCP-1) and VCAM-1. As both MCP-1 and VCAM-1 are involved with pro-inflammatory responses, NO is in this manner an anti-inflammatory agent ... 

J. Zhang (2006). Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate 66(12) 1311-1318. 

Both POVPC and PGPC can induce expression of monocyte chemotactic protein-1 (MCP-1) and IL-8 in ECs, which are well-known markers of inflammation. The signaling pathway responsible for both gene expressions was linked with activation of PPARa and transcription of genes of the PPAR response element. 

Interleukin-8, part of a supergene family of novel chemotactic cytokines (CXC and CC chemokines), is secreted by macrophages/monocytes, neutrophils, fibroblasts, and endothelial and epithehal cells in response to a variety of stimuH. A potent chemoattractant and activator of neutrophils, IL-8 may also be chemotactic for T lymphocytes (Larsen et al. 1989, Baggioloni et al. 1993). IL-8 induces the respiratory bmst in monocytes, and the structurally related chemokine monocyte chemotactic protein-1 (MCP-1) is a potent chemotactin for monocytes (Baggiolini et al. 1993). 

TNF-a induced NF-kB activation by 46%, VCAM-1 by 77-93%, monocyte chemotactic protein-1 (MCP-1) secretion by 34-124% ... 

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