Guanine monophosphate cyclic

CBF, Cerebral blood flow CCAo, common carotid artery occlusion cGMP, cyclic guanine monophosphate ICAM-1, intercellular adhesion molecule-1 ICAo, internal carotid artery occlusion MCAo, middle cerebral artery occlusion NAA, A-acetyl-aspartate NOS, nitric oxide synthase SD, Sprague-Dawley SH, spontaneously hypertensive SOD, superoxide dismutase TUNEL, transferase dUTP nick-end labeling. 

Figure 1.10 Model of a G protein-coupled receptor with 7 membrane-spanning domains. Binding of an agonist to the receptor causes GDP to exchange with GTP. The a-GTP complex then dissociates from the receptor and the py complex and interacts with intercellular en mes or ion channels. The Py complex can activate an ion channel or possibly also interact with intercellular enzymes. GDP, guanine diphosphate GTP, guanine triphosphate cAMP, cyclic adenosine monophosphate PKC, protein kinase C PLC, phospholipase C DAG, diacylglycerol.

Hole EO, Sagstuen E, Nelson WH, Close DM (1992b) The structure of the guanine cation ESR/EN-DOR of cyclic guanosine monophosphate single crystals after X irradiation at 10 K. Radiat Res 129 1-10... 

Crystals of 2 -Deoxyguanosine 5 -Monophosphate Tetrahydrate Disodium Salt (5 -dGMP) have a neutral guanine base. In the solid-state, oxidation of 5 -dGMP at 10 K leads to deprotonation at the exocyclic nitrogen which is characterized by p(C8) = 0.175 and p(N2) = 0.33 [37], The same radical was detected in crystals of 3, 5 -cyclic guanosine 5 -monohydrate. In this second study, the N3 spin density was determined to be 0.31 [38], These two studies then provide a detailed description of the amino deprotonated guanine cation G(N2-H) ... 

Figure 3.1 shows the nucleotides formed from the purine adenine - the adenine nucleotides, adenosine monophosphate (AMP), adenosine diphosphate (ADP) and adenosine triphosphate (ATP) - as well as the nucleotide triphosphates formed from the purine guanine and the pyrimidine uracil (see also section 10.3.2 for a discussion of the role of cyclic AMP in metabolic regulation and hormone action). 

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