Parathyroid hormone-related

The delicate balance maintained by these factors is altered in patients with cancer by two principal mechanisms tumor production of humoral factors that alter calcium metabolism (humoral hypercalcemia) and local osteolytic activity from bone metastases.27 Humoral hypercalcemia causes around 80% of all hypercalcemia cases and is mediated primarily by systemic secretion of parathyroid hormone-related protein... [Pg.1482]

FIGURE 96-4. Pathophysiology of the hypercalcemia of malignancy. PTHrP, parathyroid hormone-related protein TGF-P, transforming growth factor P TNF-a, tumor necrosis factor alpha Ca2+, calcium IL-1, interleukin 1 IL-2, interleukin 2. [Pg.1483]

The mechanism of G a disease may resnlt from insnfficient parathyroid hormone-related peptide signaling by the parathyroid hormone receptor 1 (PTHRl) in chondrocytes. This deficiency may inhibit the differentiation of chondrocytes within the endochondral growth plate (88,89). A variety of parathyroid hormone abnormalities can result. [Pg.85]

The parathyroid hormone receptor 1 (PTHRl) protein belongs to the GPCR family B. The PTHRl is a receptor for PTH and for parathyroid hormone-related peptide... [Pg.119]

Zhang, P., Jobert, A. S., Couvineau, A., and Silve, C. (1998) Homozygous inactivating mutation in the parathyroid hormone parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia. J. Clin. Endocrinol. Metab. 83, 3365-3368. [Pg.133]

Escande, B., Lindner, V., Massfelder, T., Helwig, J. J., and Simeoni, U. (2001). Developmental aspects of parathyroid hormone-related protein biology. Semin. Perinatol. 25, 76-84. [Pg.72]

Sanders, JL, Chattopadhyay, N, Kifor, O, Yamaguchi, T and Brown, EM, 2000, Extracellular calciumsensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Ley dig cell model of humoral hypercalcemia of malignancy, Biochem Biophys Res Commun 269 127 132... [Pg.165]

Iwamura M, Heilman J, Cockett AT, Lilja H, Gershagen S. Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen. Urology 1996 48 317-325. [Pg.73]

L5. Lerner, U. H., and Grubb, A., Human cystatin C, a cysteine proteinase inhibitor, inhibits bone resorption in vitro stimulated by parathyroid hormone and parathyroid hormone-related peptide of malignancy. J. Bone Miner. Res. 7(4), 433—440 (1992). [Pg.95]

P2. Pandian, M. R., Morgan, C. H., Carlton, E., and Serge, G. V., Modified immunoradiometric assay of parathyroid hormone-related protein Clinical application in the differential diagnosis of hypercalcemia. Clin. Chem. 38, 282-288 (1992). [Pg.292]

Parathyroid hormone-related protein receptor is a GPCR that acts via a Gas (and elevation of cAMP) or via Gaq (to activate PLC, increase IP3 and thence increase cytosolic Ca2+). PTH increases bone resorption and reabsorption of Ca2+ in the kidney with consequent elevation of blood Ca2+. Calcitonin, which binds to a GPCR that acts via a Gas to elevate C.AMP, has opposing effects to those of PTH. [Pg.167]

Parathyroid hormone/ parathyroid hormone-related protein receptor (PTH-R)... [Pg.225]

Parathyroid hormone-related protein (PTHrP)] (protein)... [Pg.225]

E. Peggion, A. Bisello, M. Rosenblatt, M. Chorev, D. F. Mierke, Mono- and bicyclic analogs of parathyroid hormone-related protein. 2. Conformational analysis of antagonists by CD, NMR, and distance geometry calculations, Biochemistry 1997, 36, 3300-3307. [Pg.323]

Rabbani, S. A., Gladu, J., Harakidas, R, Jamison, B. and Goltzman, D. (1999). Over-production of parathyroid hormone-related peptide results in increased osteolytic skeletal metastasis by prostate cancer cells in vivo. Inti. J. Cancer 80, 257-264. [Pg.325]

Parathyroid Hormone-Related Protein PTHrP was discovered in 1987 by investigators studying the mechanism by which certain cancers produce humoral hypercalcemia of malignancy (HHM). ... [Pg.1928]

Figure 49-22 PTHrP in normal subjects and patients with malignancies and other disorders. Hatched area indicates the normal reference interval. (Adapted from Pandian AIR, Morgan CH, Carlton E, Segre GV. Modified /mmunorod/ometr/c ossoy of parathyroid hormone-related protein clinical app/icatfon in the differential diagnosis of hypercalcemia. Clin Chem 1992 38 282 SS.)...

Burtis W). Parathyroid hormone-related protein structure, function, and measurement. Clin Chem 1992 38 2171-83. [Pg.1947]

Burtis WJ, Brady TG, Orlofif JJ, Ersbale JB, WarreU RP Jr, Olson BR, et al. Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. [Pg.1947]

Fraser WD, Robinson J, Lawton R, Durham B, Gallacher SJ, Boyle IT, et al. Clinical and laboratory studies of a new immunoradiometric assay of parathyroid hormone-related protein. Clin Chem 1993 39 414-19. [Pg.1950]

Hutchesson ACJ, Hughes SV, Bowden SJ, Ratdiffe WA. In vitro stability of endogenous parathyroid hormone-related-protein in blood and plasma. Ann Clin Biochem 1994 31 35-9. [Pg.1953]

Ikeda K, Ohno H, Hane M, Yokoi H, Okada M, Honma T. Development of a sensitive two-site immunoradiometric assay for parathyroid hormone-related peptide evidence for elevated levels in plasma from patient with adult T-ceU leukemia/iymphoma... [Pg.1953]

Kao PC, Klee GG, Taylor RL, Heath H III. Parathyroid hormone-related peptide in plasma of patients with hypercalcemia and malignant lesions, Mayo Clin Proc 1990 65 1399-407. [Pg.1954]

Levin GE, Nisbet JA, Stability of parathyroid hormone-related protein and parathyroid hormone at room temperature. Ann Clin Biochem 1994 31 497-500. [Pg.1955]

Moseley JM, Gillespie MT. Parathyroid hormone-related protein. Grit Rev Clin Lab Sci 1995 32 299-343. [Pg.1957]

Orloff JJ, Reddy D, De Papp AE, Soifer NE, Stewart AF. Parathyroid hormone-related protein as a prohormone posttranslational processing and receptor interactions. Endocr Rev 1994 15 40-60. [Pg.1958]

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