Intercellular adhesion molecule ICAM

Rat kidneys were perfused ex situ with phosphorothioate intercellular adhesion molecule (ICAM)-l AS-ODN and exposed to 30 min cold or warm ischaemia. After this time the kidneys were transplanted to syngeneic nephrectomized rats. Treatment with 10 mg antisense reduced the harmful effect of transplantation on renal function [132]... 

Figure 7-15 (A) Schematic diagram of the icosahedral shell of a human rhinovirus showing the arrangement of the three subunits VP1, VP2, and VP3, each present as 60 copies. (B) Stereoscopic view of an image of the virus "decorated" by the binding of two immunoglobulinlike domains of the intercellular adhesion molecule ICAM-1, a natural receptor for the virus.

Since adhesion molecules are of pivotal importance in cell trafficking and thus inflammation, they could constitute good therapeutic targets in RA. In fact, a murine mAb to intercellular adhesion molecule (ICAM)-l proved to lead to clinical improvement, (140) but repeated administration may have less effects, and the side-effect profile was also of major concern (141). Thus, anti-ICAM-1 may not be the strategy of choice. In this context it should be mentioned that TNFa blockade leads not only to clinical benefit but also to reduction of adhesion molecule expression. 

Other groups have emphasized that previous infections are an independent risk factor for acute stroke. This phenomenon might be at least in part attributable to the activation of cytokines and adhesion molecules such as the vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM) (5). 

Adhesion molecules, proteins responsible for interactions between cells and their environment, especially, the extracellular matrix and other cells. Several different molecules act as cell adhesion receptors such as integrins, intercellular adhesion molecules (ICAM), leukocyte LFA-1, Mac-1 and pl50/95 molecules, the fibronectin receptor complex fibronectin), tenascin, and the position-specific (PS) antigens of Drosophila. 

P-Selectin or intercellular adhesion molecule (ICAM)-l deficiency substantially protects E-deficient mice. 

Modulation of the expression and function of vascular graies is yet another effect exerted by oxLDLs by which these genes may participate in inflammatory and atherosclerotic processes. OxLDL increases the VCAM-1 induction response to a cytokine inflammatory signal in endothehal cells from different vaseular beds. More recently, oxLDLs have been shown to stimulate intercellular adhesion molecule (ICAM-1) expression in EC and monocyte adhesion, probably through activation of a speciflc protein tyrosine kinase (PTK). ... 

Akiyama, H, Kawamata, T., Yamada, T., Tooyama, L, and McGeer, P. L (1993) Expression of intercellular adhesion molecule (ICAM)-l by a subset of astrocytes m Alzheimer disease and some other degenerative neurological disorders Acta Neuropathol. 85,628-634. 

Cell adhesion molecule gene expression is upre-gulated in ischaemia/reperfusion. Kacimi etal. (1998) studied intercellular adhesion molecule (ICAM) response to cytokines and acute hypoxia in cultured myocardial cells. Northern blot analysis and immunoassay showed that the proinflammat-ory cytokines interleukin-ip and tumour necrosis factor-a stimulated concentration dependent in-... 

Cornelius LA, Sepp N, Li LJ, et al. Selective upregulation of intercellular adhesion molecule (ICAM-1) by ultraviolet B in human dermal microvascular endothelial cells. / Invest Dermatol. 1994 103(1) 23—28. 

Activated platelets stimulate MCP-1 and intercellular adhesion molecule (ICAM)-1 of HUVECs (50). Circulating activated platelets bind to leukocytes, preferentially monocytes, to form platelet-monocyte/leuko-cyte aggregates that interact with atherosclerotic lesions leading to the delivery of the platelet-derived chemokines and platelet factor 4 (CXCL4) to the monocyte surface and endothelium of atherosclerotic arteries (51). 

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