Intercellular adhesion molecule-1 ICAM Interleukins

HIV human immune deficiency virus HPV human papillomavirus HSV herpes simplex virus ICAM intercellular adhesion molecule IL interleukin IL-la interleukin 1 a LNA locked nucleic acid mRNA messenger RNA NK natural killer PKC protein kinase C ply rC poly ribocytosine PNA peptide nucleic acid poly rl poly ribinosine PTHrP parathyroid hormone-related peptide thermal melting temperature change in relative to DNA TAR transactivator response element VSV vesicular stomatitis virus... 

Cell adhesion molecule gene expression is upre-gulated in ischaemia/reperfusion. Kacimi etal. (1998) studied intercellular adhesion molecule (ICAM) response to cytokines and acute hypoxia in cultured myocardial cells. Northern blot analysis and immunoassay showed that the proinflammat-ory cytokines interleukin-ip and tumour necrosis factor-a stimulated concentration dependent in-... 

Abs, Antibodies CD, celiac disease EM, endomysial antibodies GFD, gluten-free diet HLA-DQ2, human leukocyte antigen ICAM, intercellular adhesion molecule IFN, interferon IL, interleukin Lab laboratory tTG, tissue transglutaminase antibodies. 

Figure 31.4. Time coui se of cellular and molecular acdvadon folowing stioke. Diagrammadc representadon of die dme course of cellular acdvadori (PNL, polymorphonuclear leukocytes M(j), macrophages) and inflammatory molecular expression (GM, granulocyte and monocyte coloriy-sdmuladng factor ICAM, soluble intercellular adhesion molecule-1 VCAM, soluble vascular- cell adliesiori molecule-1 TNF-a, tumor necrosis factor a IL-1(5, interleukin 1(5 IL-6, interleukin 6 IL-8, interleukin 8 IL-10, interleukin 10) in human brain, cerebrospinal fluid (CSF) and blood after sUoke. Reproduced from Nilupul Perera M, Ma HK, Arakawa S, Howells DW, Markus R, Rowe CC, Donnan GA (2006). InPammation following stroke. J Clin Neurosci, 13 1-8 (with permission from Elsevier).

GMP, granular membrane protein ODFR, oxygen-derived free radicals ELAM, endothelial leukocyte adhesion molecule IL-1, interleukin-1 TNF-alpha, tumor necrosis factor-alpha ICAM, intercellular adhesion molecule IFN-gamma, interferon -gamma VCAM, vascular cell adhesion molecule LFA, lymphocyte-associated antigen CR, complement receptor. 

HRT Hormone-replacement therapy ICAM-1 Intercellular adhesion molecule IDE Intermediate-density lipoprotein IHD Ischemic heart disease IL Interleukin... 

Expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) is known to be elevated at sites of inflammation. Studies have been conducted into the effects of EGCG and TF-3 on the expression of these adhesion molecules induced by interleukin-ip (IL-lp) in cultured human umbilical vein endothelial cells (HUVECs). Both compounds significantly inhibited IL-ip-induced protein expression of VCAM and ICAM in dose-dependent manners and were associated with reduced adhesion of leukocytes to HUVECs. The m-RNA level of VCAM-1 was also inhibited by these tea polyphenolics, as was the NF-KB-dependent transcriptional activity induced by IL-lp. It is concluded that these molecules exhibit anti-inflammatory and anti-invasion properties, probably via a route involving blockage of IkB kinase. 

Fig. 3. Airway inflammation and action points of erythromycin. ICAM-I, intercellular adhesion molecule-1 IL-8, interleukin-8 LTB-4, leukotriene B4.

Frohman, E. M., Frohman, T. C., Dustin, M. C., Vayuvegula, B., Choi, B., Gupta, A., van den Noort, S., and Gupta, S. (1989). The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-y, tumor necrosis factor-a, lymphotoxin, and interleukin-1 Relevance to intracerebral antigen presentation. /. Neuroimmunol. 23, 117-124. 

FIGURE 15.2 Anti-inflammatory effects exerted by liver X receptor (LXR) agonists on vascular endothelial cells (ECs), smooth muscle cells (SMCs) and macrophages. ABC, ATP-binding cassette transporter ICAM-l, intercellular adhesion molecule-1 VCAM-1, vascular cell adhesion molecule-1 IL, interleukin MMP-9, matrix metaUoprotease-9 COX-2, cyclooxygenase-2 MCP-1, monocyte chemotactic protein-1 iNOS, inducible nitric oxide synthase. 

Note IL-1 = interleukin-1 GM-CSF = granulocyte-marcophage colony-simulating factor PDGF = platelet-derived growth factor TGF-)5 = transforming growth factor-) ICAM = intercellular leukocytic adhesion molecule ELAM = extracellular leukocytic adhesion molecule. 

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