Factor inhibition

Although less widely reported than the effects of vapours, contact corrosion has been a serious problem in packaging and in electronicsAs miniaturisation and sophistication of electronic devices has increased, the hazard presented by corrosion is often the limiting factor inhibiting the attainment of expected levels of reliability. 

AML1/MTG8 Transcription factor Inhibition of cell proliferation induction of apoptosis... 

Pleiotrophin Growth factor Inhibition of colony formation decrease of in vivo tumor growth, tumor angiogenesis, and metastatic ability... 

Bacterial ribosome function Aminoglycosides Tetracyclines Chloramphenicol Macrolides, azalides Fusidic acid Mupirocin Distort SOS ribosomal subunit Block SOS ribosomal subunit Inhibits peptidyl transferase Block translocation Inhibits elongation factor Inhibits isoleucyl-tRNA synthesis No action on 40S subunit Excluded by mammalian cells No action on mammalian equivalent No action on mammalian equivalent Excluded by mammalian cells No action on mammalian equivalent... 

Prostaglandins, one of the most important epithelial growth factors, inhibit gastric acid secretion and have numerous mucosal protective effects, the most important of which include the stimulation of both mucus and phospholipid production, promotion of bicarbonate secretion, and increased mucosal cell turnover. Damage to the mucosal defense system is the primary method by which HP or NSAIDs cause peptic ulcers. 

Mechanism of Action Lithium s pharmacologic mechanism of action is not well understood and probably involves multiple effects. Possibilities include altered ion transport, increased intraneuronal catecholamine metabolism, neuroprotection or increased brain-derived neurotrophic factor, inhibition of second messenger systems, and reprogramming of gene expression.29... 

J Schemer, WA Altemeier. Experimental study of factors inhibiting absorption and effective therapeutic levels of declomycin. Surg Gynecol Obstet 114 9-14, 1962. 

Matthews, N., Neale, M.L., Jackson, S.K., and Stark, J.M., 1987, Tumor cell kilhng by tumor necrosis factor inhibition by anearobiotic condition, free-radical scavengers and inhibitors of arachidonate metabolism. Immunology 62 153-155 Miller, M.G., Rodgers, A., and Cohen, G.M., 1986, Mechanisms oftoxicity of naphthoquinones to isolated hepatocytes. Biochem. Pharmacol. 35 1177-1184 Minko, T., Kopeckova, P., and Kopecek, J., 1999, Comparison ofthe anticancer effect of free and HPMA copolymer-bound adtiamycin in human ovarian carcinoma cells. Pharmaceut. Res. 16 986-996... 

The physiological function of heparin is not completely understood. It is found only in trace amounts in normal circulating blood. It exerts an antihpemic effect by releasing lipoprotein lipase from endothehal cells heparinlike proteoglycans produced by endothelial cells have anticoagulant activity. Heparin decreases platelet and inflammatory cell adhesiveness to endothelial cells, reduces the release of platelet-derived growth factor, inhibits tumor cell metastasis, and exerts an antiproliferative effect on several types of smooth muscle. 

Tumor necrosis factor inhibition. Ethanol (95%) extract of the rhizome, in cell culture at a concentration of 100 pg/mL, was inactive on macrophage cell line RAW 264.7 vs EPS induction of TNF-az° zp Tumor promotion inhibition. Ethyl acetate and methanol extracts of the dried rhizome, in cell culture at a concentration of 50 pg/mL, produced weak activity on G3H/ lOTl/2 cells vs tetradecanoyl phorbol acetate-induced acetate phospholipid synthesis. The hexane extract was inactiveZ . Ethanol (95%) and petroleum ether extracts of the dried rhizome, in cell culture at a concentration of 160 and 80 pg/mL, re-... 

Gemmell, M.A. (1962) Natural and acquired immunity factors inhibiting penetration of some hexacanth embryos through the intestinal barrier. Nature 194, 701-702. 

Floege, J., Ostendorf, T., Janssen, U., Burg, M., Radeke, H.H., Vargeese, C. et al. (1999) Novel approach to specific growth factor inhibition in vivo—Antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. Am.J. Pathol., 154, 169-179. 

Jellinek, D., Lynott, C.K., Rifkin, D.B. and Janjic, N. (1993) High-affinity RNA ligands to basic fibroblast growth factor inhibit receptor binding. Proc. Natl. Acad. Sci. USA, 90, 11227-11231. 

As observed in the following examples, improved protein detection is therefore able to improve the detection limit even below nucleic acid-based PCR methods. In addition, many factors inhibiting the PCR of nucleic acids from a given sample were easily circumvented by the specific binding and washing steps routinely included in protein-based immunological methods. 

IL-10 is considered one of the strongest inhibitors of neutrophil functions as well as the factor inhibiting the synthesis of IL-8 and IL-la initiated by lipopoly saccharide (LPS) (S6, S8). As in the case of IL-8, IL-10 is not detectable in the serum of healthy humans, and its concentration clearly increases in patients with AP (especially in the first 72 hr of the disease course). Significantly higher concentrations... 

Groll M, Schellenberg B, Bachmann AS, ArcherCR, HuberR, Powell TK, Lindow S, Kaiser M, Dudler R (2008) A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel... 

Spyridopoulos, I., Brogi, E., Kearney, M., Sullivan, A.B., Cetrulo, C., Isner, J.M., and Losardo, D.W. 1997. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor alpha balance between growth and death signals. J. Mol. Cell. Cardiol. 29 1321-1330. 

Shoop WL, Xiong Y, Wiltsie J et al (2005) Anthrax lethal factor inhibition. Proc Natl Acad Sci USA 102 7958-7963... 

Zea mays (com) (Poaceae) Com Hageman Factor inhibitor (CHFI) (127 aa 14 kDa 10 Cys) Trypsin, Factor XHa (Hageman Factor) (inhibits a-Amylase) [323- 325]... 

Cai J, Jiang WG, Grant MB, Boulton M. Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1. J Biol Chem 2006 281 3604-3613. 

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