Breast Tumor inhibiting factors

Zhou YD et al (2005) Terpenoid tetrahydroisoquinoline alkaloids emetine, king me. and isocephae-line inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells. J Nat Prod 68(6) 947-950... 

Sacco MG, Cato EM, Ceruti R, Soldati S, Indraccolo S, Caniatti M, Scanziani E, Vezzoni P. Systemic gene therapy with anti-angiogenic factors inhibits spontaneous breast tumor growth and metastasis in MMTVneu transgenic mice. Gene Ther 2001 8 67-70. 

This compovind has been recently rediscovered in L nderfeldia sp., Dictyoceratida. Furospongolide inhibits Hypoxia-Inducible Factor 1 (HlF-1) in breast tumor cells (Liu Y. etal., 2008). 

Liu, R., Liu, Y, Zhou, Y.-D., and Nagle, D.G. (2007) Molecular-targeted antitumor agents. 15. Neolamellarins from the marine sponge Dendrilla nigra inhibit hypoxia-indudble factor-1 activation and secreted vascular endothelial growth factor production in breast tumor cells./. Nat. Prod., 70, 1741-1745. 

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