Mucosal protection

Empey, L.R., Papp, J.D., Jewell, L.D. and Fedorak, R.N. (1992). Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis. Dig. Dis. Sci. 37, 205-214. 

Prostaglandins, one of the most important epithelial growth factors, inhibit gastric acid secretion and have numerous mucosal protective effects, the most important of which include the stimulation of both mucus and phospholipid production, promotion of bicarbonate secretion, and increased mucosal cell turnover. Damage to the mucosal defense system is the primary method by which HP or NSAIDs cause peptic ulcers. 

Mucosal Protectant Sucralfate 1 g four times daily 1 g four times daily... 

Muscarinic receptor antagonists Pro ton-pump inhibitors Mucosal protective agents Pancreatic replacement enzymes Laxatives... 

Allen, A., Bell, A., and MacQueen, S. (1984). Mucus and mucosal protection. In "Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract" (A. Allen, G. Flemstrom, A. Garner, W. Silen, and L. A. Turnberg, eds), pp. 195-201. Raven Press, New York. 

NSAID with analgesic properties, and misoprostol, a Gl mucosal protective prostaglandin analog. 

Wada, I., Otaka, M., Jin, M., Odashima, M., Komatsu, K., Konishi, N., Matsuhashi, T., Horikawa, Y., Ohba, R., Itoh, H., and Watanabe, S. (2006). Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats—Correlation of HSP72 expression with mucosal protection. Biochem. Biophys. Res. Commun. 349,611-618. 

A. If the precipitant can be withdrawn then an-tisecretory treatment with a histamine H2 antagonist or proton pump inhibitor, or misoprostol (an antisecretory and mucosally protective prostaglandin) for a month may be enough to induce ulcer healing. 

Mendelson s syndrome Cytoprotectants Mucosal protective drugs Prokinetic and anti-spasmodic drugs Laxatives Anti-diarrhoeals Nausea and vomiting Pharmacology of anti-emetic drugs Other substances Non-pharmalogical therapy INTRODUCTION... 

Peptic uiceration has traditionaiiy been managed by antacid therapy—drugs that raise the pH of stomach contents by directi) neutraiising acid, or by biocking acid production. However, mucosal protective agents are now finding a piace. 

Misoprostol has both acid inhibitory and mucosal protective properties. It is believed to stimulate mucus and bicarbonate secretion and enhance mucosal blood flow. In addition, it binds to a prostaglandin receptor on parietal cells, reducing histamine-stimulated cAMP production and causing modest acid inhibition. Prostaglandins have a variety of other actions, including stimulation of intestinal electrolyte and fluid secretion, intestinal motility, and uterine contractions. 

See the section under Mucosal Protective Agents in earlier text. 

Fig. 1. Schematic diagram showing the different mechanisms of action proposed for the antiulcer action of flavonoids. 1. Blockade of add secretion by decreasing histamine production or inhibiting the proton pump. 2. Bactericidal effect on H. pylori. 3. Antioxidative activity by scavenging free radicals and preventing ROM formation. 4. Potentiation of the mucosal protective factors. PAF platelet activating factor ROM reactive oxygen metabolites H2 histamine receptor 2 M muscarinic receptor G gastrin receptor.

Wilson DE. Misoprostol and gastroduodenal mucosal protection (cytoprotection). Postgrad Med J 1988 64(Suppl 1) 7—11. 

Gyires K. Gastric mucosal protection from prostaglandins to gene-therapy. Curr Med Chem. 2005 12 203-215. 

Oral 20 mg delayed-release tablets Mucosal Protective Agents Misoprostol (Cytotec)... 

Epithelial cells Mucosal protection Fluid and electrolyte balance, mucosal secretion, and protection... 

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