Growth Hormone Release-inhibiting Factor

Somatostatin [38916-34-6] M 1637.9, [a]p -36 (c 0.57, 1% AcOH). A tetradecapeptide which is purified by gel filtration on Sephadex G-25, eluting with 2N AcOH, and then by liquid partition chromatography on Sepahdex G-25 using n-BuOH-AcOH-H20 (4 1 5) and has Rp= 0.4. It is a brain growth hormone releasing-inhibiting factor which has also been synthesised. [Burgus et al. Proc Natl Acad Sci USA 70 684 1973, Sorantakis and McKinley Biochem Biophys Res Commun 54 234 1973 Hartridt et al. Pharmazie 37 403 1982.]... 

Somatostatin SOM SST14 SST28 Somatotropin release inhibitory factor (SRIF) Growth hormone release-inhibiting factor... 

Somatostatin is a regulatory cyclic peptide, which has originally been described as a hypothalamic growth hormone release-inhibiting factor. It is produced throughout the central nervous system (CNS) as well as in secretoty cells of the periphery and mediates its regulatory functions on cellular processes such as neurotransmission, smooth muscle contraction, secretion and cell proliferation via a family of seven transmembrane domain G-protein-coupled receptors termed sstx 5. 

Growth Hormone Release-inhibiting Factor GSK3... 

Somatostatin Growth hormone-release inhibiting factor (8,9) (51110-01-1)... 

GH, growth hormone GHB, y-hydroxybutyrate GHB-R, y-hydroxybutyrate receptor GH-RIF, growth hormone-release inhibiting factor, somatostatin... 

Coy DH, Coy EJ, Arimnra A, Schally AV. Solid-phase synthesis of growth hormone-release inhibiting factor. Biochem. Biophys. Res. Commnn. 1973 54 1267-1273. 

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