Hageman factor

Silverberg M, Dunn J, Garen L, Kaplan A Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate. J Biol Chem 1980 255 7281-7286. 

Mandle RJ, Kaplan A Hageman factor substrates. Human plasma prekallikrein mechanism of activation by Hageman factor and participation in Hageman factor-dependent fibrinolysis. J Biol Chem 1977 252 6097-6104. 

Griffin JH Role of surface in surface-dependent SO activation of Hageman factor (blood coagulation factor XII). Proc Natl Acad Sci USA 1978 75 1998-2002. 

Reddigari SR, Shibayama Y. Brunnee T. Kaplan AP Human Hageman factor (factor Xll) and high molecular weight kininogen compete for the same binding site on human umbihcal vein endothelial cells. J Biol Chem 1993 268 11982-11987. 

Schreiber A, Kaplan A, Austen K Inhibition by 62 ClINH of Hageman factor fragment activation of coagulation, fibrinolysis, and kinin generation. J Clin Invest 1973 52 1402-1409. 

Kaplan A Mechanisms of activation of the classical pathway of complement by Hageman factor frag- 91 ment. J Chn Invest 1983 71 1450-1456. 

Kaplan AP, Austen KF A prealbumin activator of prekallikrein. II. Derivation of activators of prekal-likrein from active Hageman factor by digestion with plasmin. J Exp Med 1971 133 696-712. 

Dewald G, Bork K Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal Cl inhibitor. Biochem Biophys Res Commun 2006 343 1286-1289. 

H4. Hack, C. E., and Dors, D Activation and inhibition of factor XII (Hageman factor) in vivo. Curr. Opin. Invest. Drugs 1,95-110 (1992). 

Kl. Kalter, E. S., Daha, M. R Ten Cate, J. W Verhoef, J., and Bouma, B. N., Activation and inhibition of Hageman factor-dependent pathways and the complement system in uncomplicated bacteremia or bacterial shock. J. Infect. Dis. 151,1019-1027 (1985). 

XII Hageman factor Intrinsic Activated by surface contact or the kallikrenin system. Xlla helps initiate intrinsic system... 

Figure 17.1 Summary of the four cascades that result from trauma or bleeding and the reactions they catalyse. These are all activated by the blood clotting factor, Xlla (also known as the Hageman factor). Details of each cascade are presented in Figures 17.2, 17.4 and 17.6. Factor XII is activated by collagen and negatively charged surfaces to form the active form, Xlla.

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