Hormone release-inhibiting factors

Somatostatin [38916-34-6] M 1637.9, [a]p -36 (c 0.57, 1% AcOH). A tetradecapeptide which is purified by gel filtration on Sephadex G-25, eluting with 2N AcOH, and then by liquid partition chromatography on Sepahdex G-25 using n-BuOH-AcOH-H20 (4 1 5) and has Rp= 0.4. It is a brain growth hormone releasing-inhibiting factor which has also been synthesised. [Burgus et al. Proc Natl Acad Sci USA 70 684 1973, Sorantakis and McKinley Biochem Biophys Res Commun 54 234 1973 Hartridt et al. Pharmazie 37 403 1982.]... 

Somatostatin SOM SST14 SST28 Somatotropin release inhibitory factor (SRIF) Growth hormone release-inhibiting factor... 

Somatostatin is a regulatory cyclic peptide, which has originally been described as a hypothalamic growth hormone release-inhibiting factor. It is produced throughout the central nervous system (CNS) as well as in secretoty cells of the periphery and mediates its regulatory functions on cellular processes such as neurotransmission, smooth muscle contraction, secretion and cell proliferation via a family of seven transmembrane domain G-protein-coupled receptors termed sstx 5. 

Growth Hormone Release-inhibiting Factor GSK3... 

Somatostatin Growth hormone-release inhibiting factor (8,9) (51110-01-1)... 

The C-terminal tripeptide tail of oxytocin H-L-Pro-Leu-Gly-NH2 (melanocyte-stimulating hormone release inhibiting factor, MIF or melanostatin) is implicated as having a direct effect on the central nervous system. The ALeu analogue of melanostatin, [ALeu2-MIF] was prepared in view of the earlier work on the active conformation of melanostatin in which a (3-turn was implicated.11771 ALeu was prepared by the N-chlorination/dehydrochlorination reaction and then coupled with Boc-Pro-OH. 

A large number of 13C NMR studies on proline derivatives and proline peptides have appeared in the literature [815-830]. As the electron charge density of cis-proline carbons is different from that of franx-prolinc carbons, these isomers can be differentiated by nCNMR spectroscopy [826, 830]. On the basis of calculations Tonelli [831] predicted four conformations for the dipeptide Boc-Pro-Pro-OBzl, three of which could be detected by 13C NMR spectroscopy [826, 830], In proline-containing peptides the stereochemistry of the proline residue plays an important role for the conformation of these oligomers. The 13C chemical shift data of cis and trans proline derivatives, collected in Table 5.29, are useful to determine the stereochemistry of the amino acid-proline bond, e.g. in cyclo-(Pro-Gly)3, melanocyte-stimulating hormone release-inhibiting factor or thyrotropin-releasing hormone. 

GH, growth hormone GHB, y-hydroxybutyrate GHB-R, y-hydroxybutyrate receptor GH-RIF, growth hormone-release inhibiting factor, somatostatin... 

Coy DH, Coy EJ, Arimnra A, Schally AV. Solid-phase synthesis of growth hormone-release inhibiting factor. Biochem. Biophys. Res. Commnn. 1973 54 1267-1273. 

The effects of melanocyte-stimulating hormone release inhibiting factor and synthetic analogs on tolerance to and physical dependence on morphine... 

Nemifitide is a peptide analogue of melanocyte-stimulating hormone release-inhibiting factor currently in clinical development for the potential treatment of moderate to severely depressed patients (93). It is rapidly absorbed, with a peak plasma concentration of 10 min and an elimination half-life of 15 to 30 minutes in most subjects. The pharmacokinetic results indicate that the dose is proportional in the dose range investigated. 

Release inhibiting hormones, release inhibiting factors, statins. 

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