Nerve growth factor inhibition

Other therapeutic uses of cannabinoid agonists have been reported. The potential of cannabinoids as a treatment for asthma is supported experimentally. A CBi agonist, (i )-methanandamide (21), inhibited nerve growth factor (NGF)-induced airway hyperresponsiveness in vivo [251]. The antipruritic effect of cannabinoids has been reported, the action being mediated by both CBi and CB2 pathways [252]. Treatment with cannabis extract improved urinary tract symptoms of multiple sclerosis patients significantly in an open-label pilot study [253]. 

Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, et al A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 1997 94 6216-6221. 

The hereditary absence of phenylalanine hydroxylase, which is found principally in the liver, is the cause of the biochemical defect phenylketonuria (Chapter 25, Section B).430 4308 Especially important in the metabolism of the brain are tyrosine hydroxylase, which converts tyrosine to 3,4-dihydroxyphenylalanine, the rate-limiting step in biosynthesis of the catecholamines (Chapter 25), and tryptophan hydroxylase, which catalyzes formation of 5-hydroxytryptophan, the first step in synthesis of the neurotransmitter 5-hydroxytryptamine (Chapter 25). All three of the pterin-dependent hydroxylases are under complex regulatory control.431 432 For example, tyrosine hydroxylase is acted on by at least four kinases with phosphorylation occurring at several sites.431 433 4338 The kinases are responsive to nerve growth factor and epidermal growth factor,434 cAMP,435 Ca2+ + calmodulin, and Ca2+ + phospholipid (protein kinase C).436 The hydroxylase is inhibited by its endproducts, the catecholamines,435 and its activity is also affected by the availability of tetrahydrobiopterin.436... 

Chuang, H. H., E. D. Prescott, H. Kong, S. Shields, S. E. Jordt, A. I. Basbaum, M. V. Chao and D. Julius, 2001, Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition, Nature, 411, (6840), pp. 957-962... 

Mutoh, T., Tokuda, A., Inokuchi, J., and Kuriyama, M. (1998). Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC 12 cells. J. Biol. Chem. 273, 26001—26007. 

Harada, H., Sugiyama, T., Suketa, Y. (1996). Characterization of inhibition by chronic treatment with lithium ion on nerve growth factor-induced neuronal differentiation on frat PC12 pheochromocytoma cells. Journal of Toxicology and Environmental Health, 49, 197-206. 

Taglialatela G, Robinson R, Perez-Polo JR (1997) Inhibition of nuclear factor kappa B (NFkappaB) activity induces nerve growth factor-resistant apoptosis in PC12 ceUs. J Neurosci Res 47 155-162... 

Dixit VD, Schaffer EM, Pyle RS, CoUins GD, Sakthivel SK, Palaniappan R, I.illaid JW, Taub DD (2004) Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J CUn Invest 114 57-66 Dmitrieva N, Shelton D, Rice ASC, McMahon SB (1997) The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78 449-459 Doak GJ, Sawynok J (1997) Formalin-induced nodceptive behavior and edema involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes. Neuroscience 80 939-949 Dobner PR (2006) Neurotensin and pain modulation. Peptides 27 2405-2414 Dobolyi A, Ueda H, Uchida H, Palkovits M, Usdin TB (2002) Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci U S A 99 1651-1656... 

Farquhar-Smith WP, Jaggar SI, Rice AS (2002) Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors. Pain 97 11-21 Freund TF (2003) Interneuron diversity series rhythm and mood in perisomatic inhibition. 

Melck D, De Petrocellis L, Orlando P, Bisogno T, Laezza C, Bifulco M, Di Marzo V (2000) Suppression of nerve growth factor trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 141 118-126... 

Conti, A. M., Fischer, S. J., Windebank, A. J. (1977). Inhibition of axonal growth from sensory neurons by excess nerve growth factor. Ann. Neurol, 42, 838-846. 

Altin, J.G., Wetts, R. and Bradshaw, R.A. (1991) Microinjection of a p21ras antibody into PC 12 cells inhibits neurite outgrowth induced by nerve growth factor and basic fibroblast growth factor. Growth Factors 4 145-155. 

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