Inhibition Proximal to Transcription Factors

This chapter has shown that the host has multiple mechanisms for detecting viruses, while viruses have evolved numerous immunomodulatory strategies in order to achieve a more successful life cycle. Most components of the iimate immune system are targeted by multiple viruses for evasion or subversion and discoveries in this field continue at a pace which sometimes outruns and even informs the discovery of innate immune mechanisms. With the on going exploration of immunomodulation by viruses much more will be unearthed about the unknown components of antiviral signalling. In addition these studies could potentially herald more antiviral treatments. 

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Maitra RK, McMillan NA, Desai S et al. HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. Virology 1994 204(2) 823-827. 

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