Transformation of Syrian hamster cells

DiPaolo JA, Casto BC. 1979. Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts. Cancer Res 39 3008-1013. [Pg.229]

J.A. DiPaolo et al., Nitration of carcinogenic and noncarcinogenic polycyclic aromatic hydrocarbons results in products able to induce transformation of Syrian hamster cells. Carcinogenesis 4, 357-359 (1983)... [Pg.237]

Transformation of Syrian Hamster Cells by Metals. When cultures of cells were exposed to two nickel compounds with different carcinogenic potencies, there were differences in the incidence of transformed colonies that formed (Table II). Treatment with amorphous NiS resulted in a low incidence of transformation while treatment with crystalline NiaS2 induced the appearance of numerous transformed colonies (Table II). In this series of experiments, control cultures had no transformed colonies however, in some experiments there was an occasional incidence of spontaneous transformation. The induction of transformation by... [Pg.83]

Amacher DE, Zelljadt I. 1983. The morphological transformation of Syrian hamster embryo cells by chemicals reportedly nonmutagenic to Salmonella typhimurium. Carcinogenesis 4 291-295. [Pg.250]

On the other hand, mercuric chloride, at a concentration of 50 /iM, also has been shown to enhance viral transformation of Syrian hamster embryo cells [252],... [Pg.206]

Some new materials perspective for advanced biomedical technologies, especially carbon nanoparticles like fullerenes, are potentially mutagenic, carcinogenic and immunogenic [16,65], Therefore, standard tests of the morphological transformation of Syrian hamster embryonic cells in cultures on these materials (described in detail by [68,69]) can be performed. Immune activation of bone and vascular cells on the materials can be estimated by increased concentration of immunoglobulin and selectin adhesion molecules (ICAM-1, VCAM-1, ELAM-1), which bind cells of the immune system [15,16,18,19,23], as well as by the production of cytokines, such as tumor necrosis factor alpha or interleukins beta [55],... [Pg.30]

Amitrole was not genotoxic in bacterial assays and cultured mammalian cells or in rodents exposed in vivo it did induce transformation of Syrian hamster embryo cells in vitro)... [Pg.44]

The effects of split doses of x rays on the transformation of Syrian hamster embryo cells and C3H lOTl/2 cdls have been studied Borek and Hall (1974) observed that if an x-ray dose of 0.5 or 0.75 Gy (50 or 75 rad) was divided into two fractions separated by 5 hours, more cell transformation was observed than if the same dose was given in a single exposure. Cell killing, on the other hand, decreased with split doses versus single exposures. Similar split-dose studies with C3H lOTl/2 cells have indicated that the observed effect varies with the x-ray dose used At low doses (< 1 Gy < 100 rad) an enhancement in cell transformation is observed with two split doses (Miller and Hall, 1978 ... [Pg.93]

OSHIMURA, M., HESTERBERG, T.W., TSUTSUI, T, AND Barrett, J.C. (1984). Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture, Cancer Res. 44, 5017. [Pg.150]

LeBoeuf, R.A., Kcrckacrt. G.A.. Polley. J.A. Raineri, R. (1989) An interlaboratory comparison of enhanced morphological transformation of Syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH. Mutat. Res., Ill, 205-218... [Pg.398]

Toluene did not enhance morphological transformation of Syrian hamster embryo cells by the SA7 adenovirus or, as reported in an abstract, disruption of gap-junctional intercellular communication in Chinese hamster V79 cells (Awogi et al., 1986). [Pg.849]

Genotoxicity studies with A-hydroxyacetamide, a possible metabolite of acetamide, have shown that this agent is weakly mutagenic in Salmonella typhimurium and induces DNA damage in a rat hepatoma cell line. However, it did not bind covalently to DNA in vitro and did not induce morphological transformation of Syrian hamster embryo cells in vitro or inhibit gap-junctional intercellular communication in Chinese hamster lung V79 cells. [Pg.1214]

LeBoeuf RA, Kerckaert GA, Aardema MJ, Poiley JA, Raineri R (1990) Enhanced morphological and neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70. Prog Clin Biol Res 340D 219-228... [Pg.828]

DiPaolo JA, DeMarinis AJ, Doniger J. 1983. Asbestos and benzo(a)p5Tcne synergism in the transformation of Syrian hamster embryo cells. Pharmacology 27 65-73. [Pg.253]

Carcinogenic metal compoimds such as crystalline Ni3S2 induced a dose-dependent statistically significant incidence of transformation in secondary cultures of Syrian hamster cells. A chemically related compound, amorphous NiS, which is not carcinogenic, resulted in no statistically significant incidences of transformed colonies. Untreated control cultures also had no statistically significant incidence of transformation. We have... [Pg.87]

Elias Z, Poirot O, Baruthio F, et al. 1991. Role of solubilized chromium in the induction of morphological transformation of Syrian hamster embryo (SHE) cells by particulate chromium (VI) compounds. Carcinogenesis 12(10) 1811-1816. [Pg.337]

DNT, 3,4-DNT, 2,6-DNT) and technical grade DNT were unable to induce morphological transformation of Syrian hamster embryo (SHE) cells in culture, suggesting that some important activation step was missing in SHE cells [45], An example showing that some primary cells may have the ability to metabolize... [Pg.187]

Viral transformation of Syrian hamster embryo cells has also been found to be facilitated by trivalent antimony compounds (Fowler and Goering 1991). In workers at antimony smelters, an orange-red to yellowish brown discoloration of the tooth surface ( antimony teeth ) has been observed (Bencze 1994). In 1989, attention was drawn to the possible role of antimony in the sudden infant death syndrome (SIDS) (Richardson 1990). Here, it was postulated that antimony, which was present as a fire retardant in polyvinyl cot mattresses, might be converted by certain molds into tri-... [Pg.665]

Pienta, R. 1980. Transformation of Syrian hamster embryo cells by diverse chemicals and correlation with their reported carcinogenic and mutagenic activities. In Chemical Mutagens Principles and Methods for their... [Pg.88]

DiPaolo, J.A, Nelson, R.L., and Donovan, P.J., n vitro Transformation of Syrian Hamster Embryo Cells by Diverse Chemical Carcinogens , Nature (London) (1972), 2 278-280. [Pg.109]

EFFECT OF CRYATALLINE NI3S2 AND AMORPHOUS NiS ON THE TRANSFORMATION OF SYRIAN HAMSTER FETAL CELLS IN TISSUE CULTURE... [Pg.59]

EFFECT OF PRETREATMENT WITH BENZOPYRENE UPON THE TRANSFORMATION OF SYRIAN HAMSTER EMBRYO CELLS BY NICKEL COMPOUNDS... [Pg.61]

Abstract. We have reviewed work conducted in our laboratory and other laboratories investigating the carcinogenic and mutagenic effects of metals and their compounds upon in vitro systems. Preliminary data is also presented which shows the following 1) Pretreatment of Syrian hamster embryo cells with benzopyrene, an inducer of aryl hydrocarbon hydroxylase, potentiates the morphological transformation of Syrian hamster embryo cells induced by... [Pg.69]

Costa, M- Nye, J. and Sunderman, F.W., Jr. "Morphological Transformation of Syrian Hamster Fetal Cells Induced... [Pg.72]

Table 4. Transformation of Syrian hamster embryo cells exposed to X-rays or MNNG for 4 h and grown in 3-aminobenzamide for 7 days starting immediately after exposure ...

Transformation of Syrian Hamster Embryo Cells by Diverse Chemicals and Correlation with Their Reported Carcinogenic and Mutagenic Activities... [Pg.175]

Transformation of Syrian Hamster Embryo Cells by Diverse Chemicals... [Pg.177]

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